Naseri Arash, Abouali Omid, Ghalati Pejman Farhadi, Ahmadi Goodarz
School of Mechanical Engineering, Shiraz University, Shiraz, Iran.
School of Mechanical Engineering, Shiraz University, Shiraz, Iran.
Comput Biol Med. 2014 Sep;52:73-81. doi: 10.1016/j.compbiomed.2014.06.007. Epub 2014 Jun 19.
A 3-D realistic computational model of the airway system integrated into a standing male mannequin was developed. The computational domain includes the regions around the mannequin and the inside of the airway passages. The simulation was performed for low activity breathing rates with calm air around the mannequin. The flowfield of the inhaled air was first obtained from solving the Navier-Stokes and continuity equations. Then the particles were released in the domain around the mannequin and their trajectories were evaluated by using the Lagrangian approach for solving the particle equation of motion. The regional aerosols deposition was evaluated for different parts of the human airway system and the results were compared with those obtained from the separate modeling of the airway system without the interaction of the airflow with the mannequin external face. The results showed when the upper airway is integrated into the mannequin, the regional deposition of inhaled particles mainly changes in the airway system.
开发了一种集成到站立男性人体模型中的气道系统三维逼真计算模型。计算域包括人体模型周围区域和气道通道内部。在人体模型周围空气平静的情况下，针对低活动呼吸速率进行了模拟。首先通过求解纳维-斯托克斯方程和连续性方程获得吸入空气的流场。然后在人体模型周围的区域释放颗粒，并使用拉格朗日方法求解颗粒运动方程来评估它们的轨迹。评估了人类气道系统不同部位的区域气溶胶沉积，并将结果与在不考虑气流与人体模型外表面相互作用的情况下对气道系统进行单独建模所获得的结果进行了比较。结果表明，当将上呼吸道集成到人体模型中时，吸入颗粒的区域沉积主要在气道系统中发生变化。
