Exp Dermatol. 2013 May;22(5):362-3. doi: 10.1111/exd.12132.
The therapeutic effects of 5-aminolevulinic acid (ALA)-mediated photodynamic therapy (PDT) on cutaneous squamous cell carcinoma (SCC) are not fully understood, and the usefulness of topical PDT in the treatment of SCC is still debatable. The most interesting aspect in SCC PDT is perhaps its potential in inducing antitumor immune responses. In this study, cutaneous SCCs were established by UVB irradiation of hairless mice and treated with multiple ALA PDT. Immunohistochemistry assays showed that ALA PDT could induce quick apoptosis, overexpression of TNFα and marked increases in DCs, CD4(+) and CD8(+) cells in tumor interstitium and subcutaneous connective tissues. However, a complete response was only achieved for small SCCs. The clinical value of ALA PDT-induced specific antitumor immune responses in long-term control of SCCs deserves further study.
5-氨基酮戊酸（ALA）介导的光动力疗法（PDT）对皮肤鳞状细胞癌（SCC）的治疗效果尚不完全清楚，局部 PDT 在 SCC 治疗中的有效性仍存在争议。SCC-PDT 最有趣的方面可能在于其诱导抗肿瘤免疫反应的潜力。在这项研究中，通过 UVB 照射无毛小鼠建立皮肤 SCC，并采用多次 ALA-PDT 进行治疗。免疫组织化学检测显示，ALA-PDT 可诱导快速凋亡、TNFα 的过表达以及肿瘤间质和皮下结缔组织中 DC、CD4(+)和 CD8(+)细胞的显著增加。然而，仅对小型 SCC 实现了完全缓解。ALA-PDT 诱导的特异性抗肿瘤免疫反应在 SCC 长期控制中的临床价值值得进一步研究。
