Stroffolini T, Biagini W, Lorenzoni L, Palazzesi G P, Divizia M, Frongillo R
Laboratorio di Epidemiologia, Istituto Superiore di Sanità, Roma, Italy.
Eur J Epidemiol. 1990 Jun;6(2):156-9. doi: 10.1007/BF00145788.
Between September, 1988 and January, 1989 a common source outbreak of 47 cases of serologically confirmed hepatitis A occurred in a town of central Italy. Thirty-eight cases were primary, three co-primary and six secondary. The highest age-specific attack rate was seen in subjects aged 15-24 years (120 per 100,000); the mean age of cases was 24.6 years and the median age was 22 years. A matched triplet case-control study showed significant association between the disease and consumption of either raw mussels (41% of cases, compared with 10% of controls; P less than 0.0001) or a single brand of mineral water (63% of cases, compared with 41% of controls; P less than 0.05). The mean age of the cases reflects the shift in primary susceptibility to the infection from younger to older age groups, a finding which has recently been demonstrated by several seroepidemiological surveys in Italy.
