β-隐黄质对牙周炎小鼠实验模型中炎症性骨吸收的保护作用。
The protective effects of β-cryptoxanthin on inflammatory bone resorption in a mouse experimental model of periodontitis.
作者信息
Matsumoto Chiho, Ashida Noriyuki, Yokoyama Satoshi, Tominari Tsukasa, Hirata Michiko, Ogawa Kazunori, Sugiura Minoru, Yano Masamichi, Inada Masaki, Miyaura Chisato
机构信息
Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, Tokyo, Japan.
出版信息
Biosci Biotechnol Biochem. 2013;77(4):860-2. doi: 10.1271/bbb.120791.
We examined the effects of β-cryptoxanthin, a typical carotenoid, on inflammatory periodontitis. β-Cryptoxanthin suppressed lipopolysaccharide (LPS)-induced osteoclast formation in co-cultures of bone marrow cells and osteoblasts. In a mouse model of periodontitis, it suppressed bone resorption in the mandibular alveolar bone in vitro and restored alveolar bone loss induced by LPS in vivo. β-Cryptoxanthin might protect against periodontal disease.
我们研究了典型类胡萝卜素β-隐黄质对炎症性牙周炎的影响。β-隐黄质在骨髓细胞与成骨细胞的共培养体系中抑制了脂多糖（LPS）诱导的破骨细胞形成。在牙周炎小鼠模型中，它在体外抑制了下颌牙槽骨的骨吸收，并在体内恢复了由LPS诱导的牙槽骨丧失。β-隐黄质可能对牙周疾病具有保护作用。
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