Division of Basic and Clinical Immunology, Department of Medicine, University of California, Irvine, CA 92697, USA.
Gerontology. 2013;59(5):421-6. doi: 10.1159/000350536. Epub 2013 Apr 18.
Initial secretion of interferons by innate immune cells such as dendritic cells is crucial for protection against infections as well as for alerting and activating the downstream immune responses. The secretion of innate interferons, both type I and type III, by dendritic cells is severely impaired in aged subjects. This review focuses on the mechanisms responsible for the reduced interferon secretion by dendritic cells and the role this plays in the increased susceptibility of the elderly to infections, particularly of the respiratory mucosa.
先天免疫细胞（如树突状细胞）最初分泌的干扰素对于抵抗感染以及提醒和激活下游免疫反应至关重要。在老年受试者中，树突状细胞先天分泌的 I 型和 III 型干扰素均严重受损。这篇综述重点介绍了导致树突状细胞干扰素分泌减少的机制，以及这种机制在老年人易感染、特别是呼吸道黏膜感染中所起的作用。
