Costa Silva Rafael Cardoso Maciel, Bandeira-Melo Christianne, Paula Neto Heitor Afonso, Vale André Macedo, Travassos Leonardo Holanda
Laboratório de Imunoreceptores e Sinalização, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Laboratório de Inflamação, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Med Hypotheses. 2022 Oct;167:110943. doi: 10.1016/j.mehy.2022.110943. Epub 2022 Sep 9.
SARS-CoV-2 infection intrigued medicine with diverse outcomes ranging from asymptomatic to severe acute respiratory syndrome (SARS) and death. After more than two years of pandemic, reports of reinfection concern researchers and physicists. Here, we will discuss potential mechanisms that can explain reinfections, including the aggravated ones. The major topics of this hypothesis paper are the disbalance between interferon and antibodies responses, HLA heterogeneity among the affected population, and increased proportion of cytotoxic CD4+ T cells polarization in relation to T follicular cells (Tfh) subtypes. These features affect antibody levels and hamper the humoral immunity necessary to prevent or minimize the viral burden in the case of reinfections.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染引发了医学界的关注，其感染结果多种多样，从无症状感染到严重急性呼吸综合征（SARS）甚至死亡。在经历了两年多的疫情大流行之后，再次感染的报告引起了研究人员和物理学家的关注。在此，我们将讨论能够解释再次感染（包括病情加重的再次感染）的潜在机制。这篇假说论文的主要议题包括干扰素和抗体反应之间的失衡、受感染人群中的人类白细胞抗原（HLA）异质性，以及与滤泡辅助性T细胞（Tfh）亚型相关的细胞毒性CD4+ T细胞极化比例增加。这些特征会影响抗体水平，并在再次感染的情况下阻碍预防或最小化病毒载量所需的体液免疫。
