Centre for Research in Bioscience, Faculty of Health and Life Sciences, University of the West of England, Coldharbour Lane, Frenchay, Bristol BS16 1QY, UK.
Int J Oncol. 2013 Jul;43(1):194-200. doi: 10.3892/ijo.2013.1920. Epub 2013 Apr 24.
Growing evidence suggests that the flavonoid epigallocatechin-3-gallate (EGCG), notably abundant in green tea, has health-promoting properties. We examined the effect of EGCG on cell survival and apoptosis in the prostate cancer cell line PC3. Cell survival was reduced and apoptosis increased significantly with a low dose of 1 µM EGCG. The ability of the anticancer drug cisplatin to promote apoptosis was enhanced by EGCG. Furthermore, EGCG, both alone and in combination with cisplatin, promoted the expression of the pro-apoptotic splice isoform of caspase 9.
越来越多的证据表明，黄酮类化合物表没食子儿茶素-3-没食子酸酯（EGCG）具有促进健康的特性，在绿茶中含量特别丰富。我们研究了 EGCG 对前列腺癌细胞系 PC3 细胞存活和细胞凋亡的影响。低剂量 1µM EGCG 可显著降低细胞存活率并增加细胞凋亡。EGCG 可增强抗癌药物顺铂诱导细胞凋亡的能力。此外，EGCG 单独或与顺铂联合使用可促进促凋亡的半胱天冬酶 9 剪接异构体的表达。
