National Research Center of Engineering Technology for Utilization of Functional Ingredients from Botanicals, Hunan Agricultural University, Changsha, China.
Collaborative Innovation Centre of Utilization of Functional Ingredients from Botanicals, Hunan Agricultural University, Changsha, China.
Oxid Med Cell Longev. 2020 Aug 12;2020:9723686. doi: 10.1155/2020/9723686. eCollection 2020.
Epigallocatechin-3-gallate (EGCG) is the major polyphenolic compound present in green tea and is generally regarded as an effective antioxidant. However, its chemical reactivity makes it susceptible to generate reactive oxygen species (ROS) via autooxidation and exhibit prooxidant effects. The prooxidant actions of EGCG could play a dual role, being both beneficial and harmful. This review summarized recent research progress on (1) the anticancer, antiobesity, and antibacterial effects of EGCG and (2) the possible toxicity of EGCG. The major focus is on the involvement of prooxidant effects of EGCG and their effective doses used. Considering dosage is a crucial factor in the prooxidant effects of EGCG; further studies are required to find the appropriate dose at which EGCG could bring more health benefits with lower toxicity.
没食子儿茶素没食子酸酯（EGCG）是绿茶中主要的多酚类化合物，通常被认为是一种有效的抗氧化剂。然而，其化学活性使其容易通过自动氧化产生活性氧物种（ROS），并表现出促氧化剂作用。EGCG 的促氧化剂作用可能具有双重作用，既有好处也有坏处。本综述总结了 EGCG 在（1）抗癌、抗肥胖和抗菌作用，以及（2）EGCG 可能的毒性方面的最新研究进展。主要重点是 EGCG 的促氧化剂作用及其使用的有效剂量。考虑到剂量是 EGCG 促氧化剂作用的关键因素；需要进一步的研究来找到合适的剂量，使 EGCG 能在毒性更低的情况下带来更多的健康益处。
