Department of Stem Cell and Regenerative Biology, Konkuk University, Seoul 05029, Republic of Korea.
Department of Research and Innovation, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences (SIMATS), Thandalam, Chennai 602105, India.
Molecules. 2023 Feb 24;28(5):2151. doi: 10.3390/molecules28052151.
After decades of research and development concerning cancer treatment, cancer is still at large and very much a threat to the global human population. Cancer remedies have been sought from all possible directions, including chemicals, irradiation, nanomaterials, natural compounds, and the like. In this current review, we surveyed the milestones achieved by green tea catechins and what has been accomplished in cancer therapy. Specifically, we have assessed the synergistic anticarcinogenic effects when green tea catechins (GTCs) are combined with other antioxidant-rich natural compounds. Living in an age of inadequacies, combinatorial approaches are gaining momentum, and GTCs have progressed much, yet there are insufficiencies that can be improvised when combined with natural antioxidant compounds. This review highlights that there are not many reports in this specific area and encourages and recommends research attention in this direction. The antioxidant/prooxidant mechanisms of GTCs have also been highlighted. The current scenario and the future of such combinatorial approaches have been addressed, and the lacunae in this aspect have been discussed.
经过几十年的癌症治疗研究与开发,癌症仍然广泛存在,对全球人口构成巨大威胁。人们从各个可能的方向寻求癌症疗法,包括化学物质、辐射、纳米材料、天然化合物等。在本次综述中,我们调查了绿茶儿茶素取得的里程碑成就,以及在癌症治疗方面取得的成果。具体而言,我们评估了绿茶儿茶素(GTCs)与其他富含抗氧化剂的天然化合物联合使用时的协同抗癌作用。在一个不完美的时代,联合方法正在兴起,GTCs 已经取得了很大进展,但与天然抗氧化化合物联合使用时仍有不足之处可以改进。本综述强调了在这一特定领域的报告并不多,并鼓励和建议在这一方向上开展研究。我们还强调了 GTCs 的抗氧化/促氧化剂机制。本文还讨论了目前的情况和这种联合方法的未来,并讨论了这方面的空白。