Ishihara Yusuke, Kimura Shunsaku
Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-Ku, Kyoto, 615-8510, Japan.
Biopolymers. 2013 Apr;100(2):141-7. doi: 10.1002/bip.22177.
A hydrophilic cyclic tetra-β-peptide having guanine at the side chain (CPG) was synthesized to construct a four-peptide-nanotube bundle with the formation of guanine quadruplex (G-quartet). CPG was so soluble in water that molecular association of CPG was very limited in water. However, in the presence of potassium ion, circular dichroism spectral change showed initial molecular association due to the G-quartet formation followed by a slow growth into peptide nanotubes. Transmission electron microscope observation and electron diffraction analysis revealed that CPG self-assembled into a four-peptide-nanotube bundle with a uniform diameter of 7-8 nm.
合成了一种在侧链带有鸟嘌呤的亲水性环状四-β-肽（CPG），以构建形成鸟嘌呤四链体（G-四重体）的四肽纳米管束。CPG在水中的溶解度很高，以至于CPG在水中的分子缔合非常有限。然而，在钾离子存在的情况下，圆二色光谱变化显示由于G-四重体的形成导致最初的分子缔合，随后缓慢生长形成肽纳米管。透射电子显微镜观察和电子衍射分析表明，CPG自组装成直径均匀为7-8nm的四肽纳米管束。
