Tuccari G, Barresi G
Department of Human Pathology, Policlinico Universitario Gazzi, Messina, Italy.
Histopathology. 1990 Apr;16(4):377-81. doi: 10.1111/j.1365-2559.1990.tb01142.x.
Using immunoperoxidase procedures on paraffin sections, we have investigated the distribution pattern of tissue polypeptide antigen (TPA) in follicular adenomas, (20 cases), follicular carcinomas (23 cases), papillary carcinomas (10 cases), anaplastic carcinomas (eight cases) and medullary carcinomas (four cases). Normal thyroid tissue surrounding adenomas was also tested as a control. Our results document positivity for TPA in follicular, papillary and medullary carcinomas, whereas no reactivity was encountered in follicular adenomas and anaplastic carcinomas. These immunohistochemical data were compared with serological levels of TPA and the findings were discordant only for anaplastic carcinomas. We contend that the demonstration of TPA, possible in alcohol- or formalin-fixed tissues, may prove to be of value in the differential diagnosis of thyroid adenomas from carcinomas of follicular cell origin.
我们运用免疫过氧化物酶法对石蜡切片进行研究，调查了组织多肽抗原（TPA）在滤泡性腺瘤（20例）、滤泡癌（23例）、乳头状癌（10例）、未分化癌（8例）和髓样癌（4例）中的分布模式。腺瘤周围的正常甲状腺组织也作为对照进行检测。我们的结果表明，滤泡癌、乳头状癌和髓样癌中TPA呈阳性，而滤泡性腺瘤和未分化癌中未检测到反应性。这些免疫组化数据与TPA的血清学水平进行了比较，结果仅在未分化癌中不一致。我们认为，在酒精或福尔马林固定的组织中检测TPA，可能在鉴别滤泡细胞源性甲状腺腺瘤与癌方面具有价值。
