免疫细胞化学法显示黑素转铁蛋白（p97）在滤泡细胞起源的甲状腺肿瘤中的表达。
Immunocytochemical demonstration of melanotransferrin (p97) in thyroid tumors of follicular cell origin.
作者信息
Barresi G, Tuccari G
机构信息
Department of Human Pathology, University of Messina, Policlinico G. Martino, Italy.
出版信息
Pathology. 1994 Apr;26(2):127-9. doi: 10.1080/00313029400169341.
Using the PAP method on paraffin sections, we investigated the distribution pattern of melanotransferrin (p97) in follicular adenomas (20 cases), atypical adenomas (4 cases), papillary (10 cases) and follicular carcinomas (25 cases) of the thyroid; frozen sections collected from 3 follicular adenomas and 2 follicular carcinomas were also tested. Our results document positivity for p97 in atypical adenomas, papillary and follicular carcinomas, whereas no reactivity is encountered in follicular adenomas and normal portions of thyroid. We suggest that the production of p97 by neoplastic cells of atypical adenomas and differentiated thyroid carcinomas could result in a greater availability of iron for tumor cell DNA synthesis.
我们采用石蜡切片的过氧化物酶抗过氧化物酶（PAP）法，研究了黑素转铁蛋白（p97）在20例甲状腺滤泡性腺瘤、4例非典型性腺瘤、10例乳头状癌和25例滤泡状癌中的分布模式；还检测了取自3例滤泡性腺瘤和2例滤泡状癌的冰冻切片。我们的结果表明，非典型性腺瘤、乳头状癌和滤泡状癌中p97呈阳性，而滤泡性腺瘤和甲状腺正常部分未发现反应性。我们认为，非典型性腺瘤和分化型甲状腺癌的肿瘤细胞产生p97可能会使更多铁可用于肿瘤细胞DNA合成。
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