Nichols Kristen R, Edison Kari M, Rosenbaum Michelle D, Knoderer Chad A
Department of Pharmacy Practice, College of Pharmacy and Health Sciences, Butler University, Indianapolis, Indiana ; Department of Pharmacy, Riley Hospital for Children, Indiana University Health, Indianapolis, Indiana ; Department of Pediatrics, Ryan White Center for Pediatric Infectious Disease, Indiana University School of Medicine, Indianapolis, Indiana.
J Pediatr Pharmacol Ther. 2013 Jan;18(1):63-6. doi: 10.5863/1551-6776-18.1.63.
A 14-year-old male with bilateral above-the-knee amputations presented to our hospital for treatment of a skin and soft-tissue infection. We report the experience of vancomycin and gentamicin therapy in this patient. Because these medications require weight-based dosages and pharmacokinetic monitoring of serum levels, it was necessary to obtain peak and trough levels of the two drugs in order to determine the pharmacokinetic differences in this patient compared to those in an adolescent male without amputations. To our knowledge, this is the first report describing pharmacokinetic differences in an adolescent amputee.
一名14岁双侧膝上截肢男性因皮肤和软组织感染前来我院治疗。我们报告了该患者使用万古霉素和庆大霉素治疗的经验。由于这些药物需要根据体重给药并对血清水平进行药代动力学监测，因此有必要测定这两种药物的峰浓度和谷浓度，以确定该患者与未截肢青少年男性相比的药代动力学差异。据我们所知，这是第一份描述青少年截肢者药代动力学差异的报告。
