Sachdev H P, Mittal N K, Yadav H S
Department of Pediatrics, Maulana Azad Medical College, New Delhi.
Indian Pediatr. 1990 Feb;27(2):125-33.
Serum and rectal mucosal zinc content was estimated in children (6-18 months old) with acute diarrhea (Group I: n = 50), chronic diarrhea (Group II: n = 25), extraintestinal infections (Group III: n = 15) and apparently healthy controls (Group IV: n = 20). The sex and nutritional status of various groups was comparable. The mean serum and tissue zinc levels in acute (p less than 0.001) and chronic (p less than 0.05 for serum; p less than 0.001 for tissue) diarrhea groups were significantly lower than healthy and infected controls. Group II had significantly lower (p less than 0.001) serum and rectal zinc content in comparison to Group I. There was a significant negative correlation between serum zinc and diarrheal duration (r = 0.5676; p less than 0.001). Repeat estimation at discharge in 38 patients (25 in Group I, 13 in Group II) revealed a significant reduction in both tissue and serum zinc and only tissue zinc in acute and chronic diarrhea, respectively. A total of 23 patients (16 in Group I, and 7 in Group II) were evaluated 2 weeks after discharge. After discharge, at recovery there was no alteration in serum zinc, but tissue zinc was marginally higher (p greater than 0.05). It is concluded that zinc depletion occurs in diarrhea, more so in the chronic state; with the continuation of diarrhea, depletion progresses; and there is a tendency for repletion during convalescence.
对患有急性腹泻（第一组：n = 50）、慢性腹泻（第二组：n = 25）、肠外感染（第三组：n = 15）的儿童（6 - 18个月大）以及明显健康的对照组（第四组：n = 20）测定了血清和直肠黏膜锌含量。各群组的性别和营养状况具有可比性。急性腹泻组（p < 0.001）和慢性腹泻组（血清p < 0.05；组织p < 0.001）的血清和组织锌平均水平显著低于健康对照组和感染对照组。与第一组相比，第二组的血清和直肠锌含量显著更低（p < 0.001）。血清锌与腹泻持续时间之间存在显著负相关（r = 0.5676；p < 0.001）。对38例患者（第一组25例，第二组13例）出院时进行的重复测定显示，急性和慢性腹泻患者的组织锌和血清锌均显著降低，仅组织锌在慢性腹泻患者中显著降低。对23例患者（第一组16例，第二组7例）出院2周后进行了评估。出院后恢复时，血清锌无变化，但组织锌略高（p > 0.05）。得出的结论是，腹泻时会发生锌缺乏，慢性腹泻时更明显；随着腹泻持续，锌缺乏会加重；恢复期有锌补充的趋势。
