Sachdev H P, Mittal N K, Yadav H S
Department of Pediatrics, Maulana Azad Medical College, New Delhi, India.
J Pediatr Gastroenterol Nutr. 1989 Feb;8(2):212-6. doi: 10.1097/00005176-198902000-00015.
Serum and rectal mucosal copper content was estimated in children (6-18 months old) with acute diarrhea (group I: n = 50), chronic diarrhea (group II: n = 25), extraintestinal infections (group III: n = 15), and apparently healthy controls (group IV: n = 20). The sex and nutritional status of various groups was comparable. The mean serum copper levels in acute diarrhea and infected control groups were comparable, but significantly (p less than 0.001) greater in comparison to chronic diarrhea and healthy control groups. The tissue copper in group II was significantly (p less than 0.001) lower than other groups, which were comparable. There was a significant negative correlation between serum copper and diarrheal duration (r = -0.615; p less than 0.001). Repeat estimation at discharge in 38 patients (25 in group I and 13 in group II) revealed a significant (p less than 0.05) reduction in the serum and tissue copper content during this period. Among the 23 infants (16 in group I and 7 in group II) evaluated 2-3 weeks after discharge, there was an increase in copper values of tissue alone (p less than 0.05) in group I and both serum and tissue (p less than 0.05) in group II. It is concluded that elevation of serum copper in acute diarrhea is a nonspecific response to infection; infants with chronic but not acute diarrhea are copper depleted at presentation; and with the continuation of diarrhea, there is a progressive depletion of copper.
对患有急性腹泻的儿童（6 - 18个月大，第一组：n = 50）、慢性腹泻的儿童（第二组：n = 25）、肠外感染的儿童（第三组：n = 15）以及明显健康的对照组儿童（第四组：n = 20），测定了血清和直肠黏膜铜含量。各群组的性别和营养状况具有可比性。急性腹泻组和感染对照组的平均血清铜水平具有可比性，但与慢性腹泻组和健康对照组相比显著更高（p < 0.001）。第二组的组织铜含量显著低于其他具有可比性的组（p < 0.001）。血清铜与腹泻持续时间之间存在显著负相关（r = -0.615；p < 0.001）。对38例患者（第一组25例，第二组13例）出院时进行的重复测定显示，在此期间血清和组织铜含量显著降低（p < 0.05）。在出院后2 - 3周评估的23例婴儿（第一组16例，第二组7例）中，第一组仅组织铜值升高（p < 0.05），第二组血清和组织铜值均升高（p < 0.05）。得出的结论是，急性腹泻时血清铜升高是对感染的非特异性反应；慢性腹泻而非急性腹泻的婴儿在患病时铜缺乏；并且随着腹泻持续，铜会逐渐耗竭。
