Faramarzi Babak, Rich Lon J, Wu Jolan
College of Veterinary Medicine, Western University of Health Sciences, Pomona, California (Faramarzi); Antech Diagnostics, Irvine, California (Rich); Pacific Northwest University of Health Sciences, Yakima, Washington (Wu).
Can J Vet Res. 2018 Oct;82(4):287-293.
Pregnancy in many mammals, including mares, is associated with physiological changes that are reflected in hematological and biochemical profiles. Understanding those physiological changes and differentiating them from pathological changes is imperative for providing care and medical therapy in pregnant mares. Our objective was to compare normal hematological and biochemical profiles in healthy non-pregnant as well as healthy pregnant mares during the 1st and 2nd trimesters of pregnancy. Blood was collected by jugular venipuncture into ethylenediaminetetraacetic acid and serum tubes. Whole blood was analyzed using an ADVIA 120 hematologic analyzer and serum was analyzed using a Beckman Coulter AU5400. Statistical differences were detected using analysis of variance (ANOVA) and independent Student's -test; < 0.05 was considered significant. Results demonstrated higher red blood cell counts and hemoglobin concentrations and lower eosinophil counts ( < 0.001) in non-pregnant mares ( = 32) compared with pregnant mares at both 1st ( = 25) and 2nd ( = 17) trimesters. Biochemical analysis showed a significant decrease ( < 0.001) in albumin and blood urea nitrogen ( < 0.001) in the 2nd trimester and higher potassium levels ( = 0.03) in pregnant mares. Understanding such physiological changes is imperative to providing optimum care and medical treatment in mares. These data will assist clinicians to better evaluate and treat pregnant mares.
包括母马在内的许多哺乳动物在怀孕时都会出现一些生理变化，这些变化会反映在血液学和生化指标中。了解这些生理变化并将它们与病理变化区分开来，对于为怀孕母马提供护理和医疗治疗至关重要。我们的目的是比较健康未怀孕母马以及怀孕母马在妊娠前三个月和第二个三个月期间的正常血液学和生化指标。通过颈静脉穿刺将血液采集到乙二胺四乙酸管和血清管中。使用ADVIA 120血液分析仪分析全血，使用贝克曼库尔特AU5400分析仪分析血清。使用方差分析（ANOVA）和独立样本t检验检测统计学差异；P<0.05被认为具有统计学意义。结果表明，与妊娠第一个三个月（n = 25）和第二个三个月（n = 17）的怀孕母马相比，未怀孕母马（n = 32）的红细胞计数和血红蛋白浓度更高，嗜酸性粒细胞计数更低（P<0.001）。生化分析显示，妊娠第二个三个月白蛋白和血尿素氮显著降低（P<0.001），怀孕母马钾水平更高（P = 0.03）。了解这些生理变化对于为母马提供最佳护理和医疗治疗至关重要。这些数据将有助于临床医生更好地评估和治疗怀孕母马。
