Kaur S, Kanwar A J
Department of Dermatology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Int J Dermatol. 1990 Jun;29(5):371-4. doi: 10.1111/j.1365-4362.1990.tb04767.x.
Fifty patients with pemphigus (45 pemphigus vulgaris, 5 pemphigus foliaceus) were treated with dexamethasone-cyclophosphamide pulse therapy. The pulse consisted of 136 mg dexamethasone dissolved in 5% dextrose given in a drip over a period of 1-2 hours on 3 consecutive days. In addition, 500 mg cyclophosphamide was added in the drip on the first day. Such pulses were given at monthly intervals. In between the pulses patients were given 50 mg cyclophosphamide orally each day. The results were encouraging, the chief advantage being freedom from side effects of corticosteroid therapy. The lesions healed in 3-4 days and the patients were able to resume their work within one week. Further scope of such therapy in pemphigus is discussed.
五十例天疱疮患者（45例寻常型天疱疮，5例落叶型天疱疮）接受了地塞米松 - 环磷酰胺冲击疗法治疗。冲击治疗方案为：连续3天，每天将136毫克地塞米松溶解于5%葡萄糖溶液中，在1 - 2小时内静脉滴注完毕。此外，第一天的滴注液中加入500毫克环磷酰胺。此类冲击治疗每月进行一次。在两次冲击治疗期间，患者每天口服50毫克环磷酰胺。结果令人鼓舞，主要优点是避免了皮质类固醇治疗的副作用。皮损在3 - 4天内愈合，患者能够在一周内恢复工作。文中还讨论了这种疗法在天疱疮治疗中的进一步应用范围。
