巴西天疱疮患者样本中代谢综合征及其组成成分的患病率。
Prevalence of Metabolic Syndrome and its components in a Brazilian sample of pemphigus patients.
作者信息
Ambiel Marcela Vendruscolo, Roselino Ana Maria
机构信息
Universidade de São Paulo, Ribeirão Preto, SP, Brazil.
出版信息
An Bras Dermatol. 2014 Sep-Oct;89(5):752-6. doi: 10.1590/abd1806-4841.20142930.
BACKGROUND
Pemphigus foliaceus and pemphigus vulgaris are endemic in the northeastern region of São Paulo State, Brazil. They are treated mainly with systemic corticosteroids, which may provoke osteoporosis; atherosclerosis, higher blood pressure, insulin resistance, glucose intolerance, hyperlipidemia and abdominal obesity. These side effects of corticoids also constitute criteria for the diagnosis of metabolic syndrome.
OBJECTIVE
The prevalence of metabolic syndrome and each component of metabolic syndrome in Pemphigus foliaceus and pemphigus vulgaris groups was compared with Brazilian casuistic samples.
METHODS
Data of 147 patients (pemphigus foliaceus 48.9% and pemphigus vulgaris 51.1%) were compiled from medical records regarding metabolic syndrome and its components, and included in the analysis.
RESULTS
There was no significant difference regarding the prevalence of metabolic syndrome in pemphigus groups compared with the Brazilian casuistic samples. The analysis of each component of metabolic syndrome showed a higher prevalence of: higher blood pressure in male subjects with pemphigus vulgaris, and in pemphigus foliaceus in both genders; diabetes mellitus in both genders for pemphigus vulgaris and pemphigus foliaceus; obesity in females for pemphigus vulgaris and pemphigus foliaceus, and hypertriglyceridemia in both genders for pemphigus vulgaris and pemphigus foliaceus groups that were statistically significant compared to the Brazilian reports. Furthermore, the study noted a higher incidence of cardiovascular events in both genders in pemphigus foliaceus and pemphigus vulgaris groups than in Brazilian casuistic samples.
CONCLUSION
The components of metabolic syndrome are more numerous in pemphigus when compared with Brazilian casuistic samples. Future studies are necessary to assure that metabolic syndrome may be associated with pemphigus per se, including a greater casuistic sample of patients who have not taken corticoids.
背景
落叶型天疱疮和寻常型天疱疮在巴西圣保罗州东北部为地方病。它们主要用全身性皮质类固醇进行治疗，这可能引发骨质疏松、动脉粥样硬化、高血压、胰岛素抵抗、葡萄糖不耐受、高脂血症和腹部肥胖。皮质类固醇的这些副作用也构成了代谢综合征的诊断标准。
目的
将落叶型天疱疮和寻常型天疱疮组中代谢综合征及其各组分的患病率与巴西病例样本进行比较。
方法
从病历中收集了147例患者（落叶型天疱疮占48.9%，寻常型天疱疮占51.1%）有关代谢综合征及其组分的数据，并纳入分析。
结果
与巴西病例样本相比，天疱疮组中代谢综合征的患病率无显著差异。对代谢综合征各组分的分析显示，以下情况的患病率较高：寻常型天疱疮男性患者以及落叶型天疱疮男女患者的高血压；寻常型天疱疮和落叶型天疱疮男女患者的糖尿病；寻常型天疱疮和落叶型天疱疮女性患者的肥胖；以及寻常型天疱疮和落叶型天疱疮组男女患者的高甘油三酯血症，与巴西报告相比具有统计学意义。此外，该研究指出，落叶型天疱疮和寻常型天疱疮组男女心血管事件的发生率均高于巴西病例样本。
结论
与巴西病例样本相比，天疱疮患者中代谢综合征的组分更多。有必要开展进一步研究，以确定代谢综合征是否可能与天疱疮本身相关，包括纳入更多未使用过皮质类固醇的患者病例样本。
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