天疱疮的脉冲疗法：11例报告。
Pulse therapy in pemphigus: report of 11 cases.
作者信息
Fernandes Nurimar Conceição, Menezes Mariana
机构信息
School of Medicine, Federal University of Rio de Janeiro.
出版信息
An Bras Dermatol. 2013 Jul-Aug;88(4):672-5. doi: 10.1590/abd1806-4841.20131840.
In this study, five cases of pemphigus vulgaris and two cases of pemphigus foliaceus were treated with cyclophosphamide pulse therapy associated with prednisone, resulting in the need for a smaller maintenance dose of prednisone. In three cases of pemphigus vulgaris and one case of pemphigus foliaceus, dexamethasone and cyclophosphamide pulse therapy associated with prednisone helped the lesions to heal more rapidly. Neither treatment however prevented the recurrence of the disease. Amenorrhea, myelotoxicity and Stevens-Johnson syndrome were among the cyclophosphamide side effects. All the patients treated with prednisone experienced known side effects.
在本研究中，5例寻常型天疱疮和2例落叶型天疱疮患者接受了环磷酰胺冲击疗法联合泼尼松治疗，从而使得泼尼松维持剂量减小。在3例寻常型天疱疮和1例落叶型天疱疮患者中，地塞米松和环磷酰胺冲击疗法联合泼尼松治疗使皮损愈合更快。然而，两种治疗均未能预防疾病复发。闭经、骨髓毒性和史蒂文斯-约翰逊综合征均为环磷酰胺的副作用。所有接受泼尼松治疗的患者均出现了已知的副作用。
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