Pouliot M C, Després J P, Nadeau A, Tremblay A, Moorjani S, Lupien P J, Thériault G, Bouchard C
Physical Activity Sciences Laboratory, Laval University, Ste-Foy, Quebec, Canada.
Int J Obes. 1990 Apr;14(4):293-302.
The associations between total adiposity, body fat distribution measured by computed tomography (CT) and estimated by the waist-to-hip ratio (WHR), regional fat cell morphology, fasting plasma free fatty acid (FFA) levels and glucose tolerance were studied in a sample of 37 premenopausal women aged 35.3 +/- 4.6 years (mean +/- s.d.). Body fat mass, CT-derived abdominal and femoral fat areas, as well as the abdominal fat cell weight were all significantly associated with fasting plasma FFA levels (0.34 less than r less than 0.49, 0.005 less than P less than 0.05), and with the glucose and insulin areas during the oral glucose tolerance test (OGTT) (0.36 less than r less than 0.70, 0.0001 less than P less than 0.05). No associations were found between the WHR, the femoral fat cell weight and fasting plasma FFA levels or glucose area during the OGTT. However, the WHR and the femoral fat cell weight were positively associated with insulin area. Plasma FFA levels were positively correlated with the glucose area during the OGTT, whereas no association was found between plasma FFA levels and the insulin area. Covariance analysis indicated that this effect of plasma FFA levels on the magnitude of glucose response to OGTT was independent from that of total adiposity or regional body fat distribution variables. These results emphasize the importance of plasma FFA levels as a correlate of glucose tolerance and suggest that the associations previously reported between obesity, regional body fat distribution, fat cell size and glucose tolerance are, at least partly, mediated by variations in plasma FFA levels.
在37名年龄为35.3±4.6岁（均值±标准差）的绝经前女性样本中，研究了总体肥胖、通过计算机断层扫描（CT）测量并通过腰臀比（WHR）估算的体脂分布、局部脂肪细胞形态、空腹血浆游离脂肪酸（FFA）水平与葡萄糖耐量之间的关联。体脂量、CT衍生的腹部和股部脂肪面积以及腹部脂肪细胞重量均与空腹血浆FFA水平显著相关（0.34＜r＜0.49，0.005＜P＜0.05），并且与口服葡萄糖耐量试验（OGTT）期间的葡萄糖和胰岛素面积相关（0.36＜r＜0.70，0.0001＜P＜0.05）。未发现WHR、股部脂肪细胞重量与空腹血浆FFA水平或OGTT期间的葡萄糖面积之间存在关联。然而，WHR和股部脂肪细胞重量与胰岛素面积呈正相关。血浆FFA水平与OGTT期间的葡萄糖面积呈正相关，而血浆FFA水平与胰岛素面积之间未发现关联。协方差分析表明，血浆FFA水平对OGTT葡萄糖反应幅度的这种影响独立于总体肥胖或局部体脂分布变量的影响。这些结果强调了血浆FFA水平作为葡萄糖耐量相关因素的重要性，并表明先前报道的肥胖、局部体脂分布、脂肪细胞大小与葡萄糖耐量之间的关联至少部分是由血浆FFA水平的变化介导的。
