Mauriège P, Després J P, Moorjani S, Prud'Homme D, Lamarche B, Bouchard C, Nadeau A, Tremblay A, Lupien P J
Lipid Research Center, Laval University Medical Research Center, Ste-Foy, Québec, Canada.
Eur J Clin Invest. 1993 Nov;23(11):729-40. doi: 10.1111/j.1365-2362.1993.tb01293.x.
The relationships between subcutaneous abdominal and femoral fat cell lipolyses, plasma free-fatty acid (FFA) levels and metabolic variables considered as risk factors for cardiovascular disease (CVD) (plasma glucose, insulin and lipoprotein levels) were investigated in 54 men, aged 36 +/- 3 (SD) years, covering a wide range of body fatness values (body mass indices from 19 to 34 kg m-2). Although there were no consistent relationships between femoral fat cell weight and the metabolic profile, positive and significant associations were found between abdominal fat cell weight and most of the metabolic indices. However, abdominal fat cell lipolysis measured with an alpha 2-(clonidine) or a beta-agonist (isoproterenol) was unrelated to metabolic variables. In contrast, femoral fat cell lipolysis measured in the presence of clonidine was positively associated with fasting plasma insulin, cholesterol (CHOL) and apolipoprotein (apo) B levels, as well as with LDL-CHOL and LDL-apo B concentrations. No association was found between isoproterenol-stimulated lipolysis of femoral adipocytes and the metabolic profile. Comparison of two subgroups of men with either low or high femoral residual lipolysis with clonidine revealed that subjects with the lowest femoral alpha 2-adrenergic component (i.e. the highest residual lipolysis) displayed significant alterations in both plasma lipid-lipoprotein and glucose-insulin levels which could be predictive of an increased risk of CVD. Free fatty acid (FFA) levels measured in the fasting state and during an oral glucose tolerance test (OGTT) were positively associated with fasting plasma insulin and triglyceride levels as well as with both glucose and insulin areas measured during the OGTT. However, regional adipose tissue lipolysis measured in vitro was unrelated to plasma FFA levels. These results support the view that both femoral adipose tissue lipolysis and plasma FFA levels are significant correlates of plasma glucose-insulin homeostasis and lipoprotein-lipid levels, in men. However, as adipose tissue lipolysis and plasma FFA are unrelated to each other, they may be associated with risk variables through independent mechanisms.
对54名年龄在36±3（标准差）岁的男性进行了研究，这些男性身体脂肪值范围广泛（体重指数从19至34kg/m²），旨在探究腹部皮下脂肪和股部脂肪细胞脂解与血浆游离脂肪酸（FFA）水平以及被视为心血管疾病（CVD）风险因素的代谢变量（血浆葡萄糖、胰岛素和脂蛋白水平）之间的关系。尽管股部脂肪细胞重量与代谢谱之间没有一致的关系，但腹部脂肪细胞重量与大多数代谢指标之间存在正相关且显著的关联。然而，用α₂-（可乐定）或β-激动剂（异丙肾上腺素）测量的腹部脂肪细胞脂解与代谢变量无关。相反，在可乐定存在的情况下测量的股部脂肪细胞脂解与空腹血浆胰岛素、胆固醇（CHOL）和载脂蛋白（apo）B水平以及低密度脂蛋白胆固醇（LDL-CHOL）和低密度脂蛋白载脂蛋白B浓度呈正相关。未发现异丙肾上腺素刺激的股部脂肪细胞脂解与代谢谱之间存在关联。对可乐定刺激后股部残余脂解低或高的两个男性亚组进行比较发现，股部α₂-肾上腺素能成分最低（即残余脂解最高）的受试者在血浆脂质-脂蛋白和葡萄糖-胰岛素水平方面均有显著改变，这可能预示着心血管疾病风险增加。在空腹状态和口服葡萄糖耐量试验（OGTT）期间测量的游离脂肪酸（FFA）水平与空腹血浆胰岛素和甘油三酯水平以及OGTT期间测量的葡萄糖和胰岛素曲线下面积呈正相关。然而，体外测量的局部脂肪组织脂解与血浆FFA水平无关。这些结果支持这样一种观点，即股部脂肪组织脂解和血浆FFA水平均是男性血浆葡萄糖-胰岛素稳态和脂蛋白-脂质水平的重要相关因素。然而，由于脂肪组织脂解与血浆FFA彼此无关，它们可能通过独立机制与风险变量相关联。
