Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory for Biocontrol, Sun Yat-sen University, Guangzhou 510275, China.
J Genet Genomics. 2013 Apr 20;40(4):143-52. doi: 10.1016/j.jgg.2013.03.002. Epub 2013 Mar 14.
MicroRNAs (miRNAs) are a class of endogenous small non-coding RNAs that modulate diverse biological processes predominantly by translation inhibition or induction of mRNA degradation. They are important regulatory elements involved in renal physiology and pathology. Dysregulation of miRNAs disrupts early kidney development, renal progenitor cell differentiation and the maintenance of mature nephrons. miRNAs are also reported to participate in various renal diseases, including chronic kidney disease, acute kidney injury, allograft acute rejection and renal cell carcinoma. Differentially regulated miRNAs may represent innovative biomarkers for diagnosis and prognosis. Therefore, determining the roles of miRNAs in different types of renal diseases will help to clarify the pathogenesis and facilitate the development of novel therapies.
MicroRNAs (miRNAs) 是一类内源性的小型非编码 RNA，主要通过翻译抑制或诱导 mRNA 降解来调节多种生物学过程。它们是参与肾脏生理和病理的重要调节因子。miRNAs 的失调会破坏早期肾脏发育、肾祖细胞分化和成熟肾单位的维持。也有报道称，miRNAs 参与各种肾脏疾病，包括慢性肾脏病、急性肾损伤、同种异体肾移植急性排斥反应和肾细胞癌。差异调节的 miRNAs 可能代表诊断和预后的创新生物标志物。因此，确定 miRNAs 在不同类型肾脏疾病中的作用将有助于阐明发病机制并促进新疗法的开发。
