Kaida Hayato, Toh Uhi, Hayakawa Masanobu, Hattori Satoshi, Fujii Teruhiko, Kurata Seiji, Kawahara Akihiko, Hirose Yasumitsu, Kage Masayoshi, Ishibashi Masatoshi
Department of Radiology, PET Center, Division of Nuclear Medicine, Kurume University School of Medicine, Fukuoka, Japan.
Nucl Med Commun. 2013 Jun;34(6):562-70. doi: 10.1097/MNM.0b013e328360d945.
This study was conducted to evaluate the relationship between fluorine-18 fluorodeoxyglucose metabolic parameters [maximum standardized uptake value (SUV(max)), metabolic tumor volume (MTV), and total lesion glycolysis (TLG)] and clinicopathological factors of breast cancer.
The study comprised 93 patients. A volumetric region of interest was drawn over the abnormal focal uptake of breast cancer. Spearman's rank correlation, the Kruskal-Wallis test, and receiver operating characteristic analysis were used to investigate the relationship between clinicopathological factors and metabolic parameters and determine which metabolic parameters were most highly associated with clinicopathological factors.
All parameters had a statistically significant relationship with pathological T stage (p-T stage), pathological N status (p-N status), pathological stage (p-stage), and triple-negative type (TN) (all P values were <0.05). There were statistically significant differences between SUV(max) and TLG in relation to lymphatic invasion, estrogen receptor, and nuclear grade (P<0.05). High MTV showed a tendency toward association with estrogen receptor negativity, but the relation did not reach the level of statistical significance (P=0.056). No statistically significant relationship was observed between MTV and lymphatic invasion or nuclear grade. In the receiver operating characteristic analysis of p-T stage and p-stage, the AUC for TLG was significantly larger than that for SUV(max) (P=0.0003 and 0.048, respectively). There were marginally significant differences between TLG and MTV in relation to p-stage (P=0.058).
TLG may reflect tumor metabolism for clinicopathological factors of breast cancer better than SUV(max) or MTV.
本研究旨在评估氟-18氟脱氧葡萄糖代谢参数[最大标准化摄取值（SUV(max)）、代谢肿瘤体积（MTV）和总病变糖酵解（TLG）]与乳腺癌临床病理因素之间的关系。
该研究纳入了93例患者。在乳腺癌异常局灶摄取区域绘制体积感兴趣区。采用Spearman等级相关性分析、Kruskal-Wallis检验和受试者工作特征分析来研究临床病理因素与代谢参数之间的关系，并确定哪些代谢参数与临床病理因素相关性最高。
所有参数与病理T分期（p-T分期）、病理N状态（p-N状态）、病理分期（p分期）和三阴性类型（TN）均具有统计学显著关系（所有P值均<0.05）。SUV(max)和TLG在淋巴管侵犯、雌激素受体和核分级方面存在统计学显著差异（P<0.05）。高MTV显示出与雌激素受体阴性相关的趋势，但该关系未达到统计学显著水平（P=0.056）。未观察到MTV与淋巴管侵犯或核分级之间存在统计学显著关系。在p-T分期和p分期的受试者工作特征分析中，TLG的曲线下面积显著大于SUV(max)（分别为P=0.0003和0.048）。TLG和MTV在p分期方面存在边缘显著差异（P=0.058）。
对于乳腺癌的临床病理因素，TLG可能比SUV(max)或MTV更好地反映肿瘤代谢。
