相似文献
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Autoimmunity risk alleles: hotspots in B cell regulatory signaling pathways.自身免疫风险等位基因：B 细胞调控信号通路中的热点。
J Clin Invest. 2013 May;123(5):1928-31. doi: 10.1172/JCI69289. Epub 2013 Apr 24.
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A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models.一种与疾病相关的 PTPN22 变异体可在小鼠模型中促进全身性自身免疫。
J Clin Invest. 2013 May;123(5):2024-36. doi: 10.1172/JCI66963. Epub 2013 Apr 24.
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The putative role of the C1858T polymorphism of protein tyrosine phosphatase PTPN22 gene in autoimmunity.蛋白酪氨酸磷酸酶 PTPN22 基因 C1858T 多态性在自身免疫中的推测作用。
Autoimmun Rev. 2013 May;12(7):717-25. doi: 10.1016/j.autrev.2012.12.003. Epub 2012 Dec 20.
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Autoimmunity in primary antibody deficiency is associated with protein tyrosine phosphatase nonreceptor type 22 (PTPN22).原发性抗体缺陷中的自身免疫与蛋白酪氨酸磷酸酶非受体型 22（PTPN22）有关。
J Allergy Clin Immunol. 2013 Apr;131(4):1130-5, 1135.e1. doi: 10.1016/j.jaci.2012.06.023. Epub 2012 Jul 31.
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Tyrosine phosphatase PTPN22: multifunctional regulator of immune signaling, development, and disease.酪氨酸磷酸酶PTPN22：免疫信号传导、发育和疾病的多功能调节因子。
Annu Rev Immunol. 2014;32:83-119. doi: 10.1146/annurev-immunol-032713-120249. Epub 2013 Dec 18.
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Low Frequencies of Autoimmunity-Associated PTPN22 Polymorphisms in MODY Patients, Including Those Transiently Expressing Islet Cell Autoantibodies.青少年发病的成年型糖尿病（MODY）患者中自身免疫相关PTPN22多态性的低频情况，包括那些短暂表达胰岛细胞自身抗体的患者。
Int Arch Allergy Immunol. 2015;166(3):189-98. doi: 10.1159/000380853. Epub 2015 Apr 18.
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The common, autoimmunity-predisposing 620Arg > Trp variant of PTPN22 modulates macrophage function and morphology.常见的、自身免疫易感性的 PTPN22 620Arg>Trp 变异体调节巨噬细胞功能和形态。
J Autoimmun. 2017 May;79:74-83. doi: 10.1016/j.jaut.2017.01.009. Epub 2017 Feb 22.
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Cutting edge: the PTPN22 allelic variant associated with autoimmunity impairs B cell signaling.前沿：与自身免疫相关的PTPN22等位基因变体损害B细胞信号传导。
J Immunol. 2009 Mar 15;182(6):3343-7. doi: 10.4049/jimmunol.0713370.
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PTPN22 deficiency cooperates with the CD45 E613R allele to break tolerance on a non-autoimmune background.蛋白酪氨酸磷酸酶非受体型22（PTPN22）缺陷与CD45 E613R等位基因协同作用，在非自身免疫背景下破坏免疫耐受。
J Immunol. 2009 Apr 1;182(7):4093-106. doi: 10.4049/jimmunol.0803317.
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The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humans.编码 R620W 变异的 PTPN22 等位基因干扰人类中自身反应性 B 细胞的清除。
J Clin Invest. 2011 Sep;121(9):3635-44. doi: 10.1172/JCI45790. Epub 2011 Aug 1.
引用本文的文献
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Naturally occurring autoimmune disease in (NZB X NZW) F1 mice is correlated with suppression of MZ B cell development due to aberrant B Cell Receptor (BCR) signaling, which is exacerbated by exposure to inorganic mercury.（新西兰黑鼠×新西兰白鼠）F1代小鼠的自然发生的自身免疫性疾病与由于异常B细胞受体（BCR）信号传导导致的边缘区B细胞发育受抑制相关，而暴露于无机汞会加剧这种情况。
Toxicol Sci. 2023 Nov 11;197(2):211-21. doi: 10.1093/toxsci/kfad120.
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Mercury intoxication disrupts tonic signaling in B cells, and may promote autoimmunity due to abnormal phosphorylation of STIM-1 and other autoimmunity risk associated phosphoproteins involved in BCR signaling.汞中毒会破坏 B 细胞的紧张信号，并可能由于 STIM-1 的异常磷酸化和 BCR 信号转导中涉及的其他自身免疫风险相关磷酸化蛋白导致自身免疫。
Toxicol Appl Pharmacol. 2023 Sep 1;474:116607. doi: 10.1016/j.taap.2023.116607. Epub 2023 Jun 20.
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Polygenic autoimmune disease risk alleles impacting B cell tolerance act in concert across shared molecular networks in mouse and in humans.多基因自身免疫性疾病风险等位基因在小鼠和人类的共享分子网络中协同作用，影响 B 细胞耐受。
Front Immunol. 2022 Aug 24;13:953439. doi: 10.3389/fimmu.2022.953439. eCollection 2022.
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A Precision B Cell-Targeted Therapeutic Approach to Autoimmunity Caused by Phosphatidylinositol 3-Kinase Pathway Dysregulation.靶向磷脂酰肌醇 3-激酶通路失调的自身免疫性疾病的精准 B 细胞治疗方法。
J Immunol. 2019 Jun 15;202(12):3381-3393. doi: 10.4049/jimmunol.1801394. Epub 2019 May 10.
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High prevalence of protein tyrosine phosphatase non-receptor N22 gene functional variant R620W in systemic lupus erythematosus patients from Kuwait: implications for disease susceptibility.科威特系统性红斑狼疮患者中蛋白酪氨酸磷酸酶非受体N22基因功能变异体R620W的高患病率：对疾病易感性的影响
BMC Rheumatol. 2018 Mar 16;2:7. doi: 10.1186/s41927-018-0015-x. eCollection 2018.
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Association of PTPN22 1858C/T Polymorphism with Autoimmune Diseases: A Systematic Review and Bayesian Approach.蛋白酪氨酸磷酸酶非受体型22（PTPN22）1858C/T多态性与自身免疫性疾病的关联：一项系统评价和贝叶斯方法
J Clin Med. 2019 Mar 12;8(3):347. doi: 10.3390/jcm8030347.
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The Autoimmune-Associated Single Nucleotide Polymorphism Within Correlates With Clinical Outcome After Lung Transplantation.自身免疫相关的单核苷酸多态性与肺移植后的临床结果相关。
Front Immunol. 2019 Jan 17;9:3105. doi: 10.3389/fimmu.2018.03105. eCollection 2018.
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Putting on the Brakes: Regulatory Kinases and Phosphatases Maintaining B Cell Anergy.刹车机制：调控激酶和磷酸酶维持 B 细胞失能
Front Immunol. 2018 Apr 6;9:665. doi: 10.3389/fimmu.2018.00665. eCollection 2018.
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Lyn, Lupus, and (B) Lymphocytes, a Lesson on the Critical Balance of Kinase Signaling in Immunity.琳、狼疮和（B）淋巴细胞，关于免疫中激酶信号关键平衡的一堂课。
Front Immunol. 2018 Mar 1;9:401. doi: 10.3389/fimmu.2018.00401. eCollection 2018.
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Regulation of autoimmune and anti-tumour T-cell responses by PTPN22.PTPN22 调节自身免疫和抗肿瘤 T 细胞反应。
Immunology. 2018 Jul;154(3):377-382. doi: 10.1111/imm.12919. Epub 2018 Apr 16.
本文引用的文献
1
A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models.一种与疾病相关的 PTPN22 变异体可在小鼠模型中促进全身性自身免疫。
J Clin Invest. 2013 May;123(5):2024-36. doi: 10.1172/JCI66963. Epub 2013 Apr 24.
2
CSK regulatory polymorphism is associated with systemic lupus erythematosus and influences B-cell signaling and activation.CSK 调节多态性与系统性红斑狼疮有关，并影响 B 细胞信号转导和激活。
Nat Genet. 2012 Nov;44(11):1227-30. doi: 10.1038/ng.2439. Epub 2012 Oct 7.
3
Interaction of TAPP adapter proteins with phosphatidylinositol (3,4)-bisphosphate regulates B-cell activation and autoantibody production.TAPP 衔接蛋白与磷脂酰肌醇（3,4）-二磷酸的相互作用调节 B 细胞的激活和自身抗体的产生。
Eur J Immunol. 2012 Oct;42(10):2760-70. doi: 10.1002/eji.201242371. Epub 2012 Aug 8.
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Transcriptional effects of a lupus-associated polymorphism in the 5' untranslated region (UTR) of human complement receptor 2 (CR2/CD21).狼疮相关多态性在人类补体受体 2（CR2/CD21）5'非翻译区（UTR）的转录效应。
Mol Immunol. 2012 Oct;52(3-4):165-73. doi: 10.1016/j.molimm.2012.04.013. Epub 2012 Jun 4.
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The functions and regulation of the PTEN tumour suppressor.PTEN 肿瘤抑制因子的功能与调节。
Nat Rev Mol Cell Biol. 2012 Apr 4;13(5):283-96. doi: 10.1038/nrm3330.
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Central B-cell tolerance: where selection begins.中枢 B 细胞耐受：选择开始的地方。
Cold Spring Harb Perspect Biol. 2012 Apr 1;4(4):a007146. doi: 10.1101/cshperspect.a007146.
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Monophosphorylation of CD79a and CD79b ITAM motifs initiates a SHIP-1 phosphatase-mediated inhibitory signaling cascade required for B cell anergy.CD79a 和 CD79b ITAM 基序的单磷酸化启动了需要 B 细胞失能的SHIP-1 磷酸酶介导的抑制性信号级联反应。
Immunity. 2011 Nov 23;35(5):746-56. doi: 10.1016/j.immuni.2011.10.011. Epub 2011 Nov 9.
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Genetic and physical interaction of the B-cell systemic lupus erythematosus-associated genes BANK1 and BLK.B 细胞系统性红斑狼疮相关基因 BANK1 和 BLK 的遗传和物理相互作用。
Ann Rheum Dis. 2012 Jan;71(1):136-42. doi: 10.1136/annrheumdis-2011-200085. Epub 2011 Oct 6.
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The autoimmune disease-associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness.自身免疫性疾病相关的 PTPN22 变体促进钙蛋白酶介导的 Lyp/Pep 降解，与淋巴细胞和树突状细胞的高反应性相关。
Nat Genet. 2011 Aug 14;43(9):902-7. doi: 10.1038/ng.904.
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Risk alleles for systemic lupus erythematosus in a large case-control collection and associations with clinical subphenotypes.在一个大型病例对照研究集中的系统性红斑狼疮风险等位基因，以及与临床亚表型的关联。
PLoS Genet. 2011 Feb;7(2):e1001311. doi: 10.1371/journal.pgen.1001311. Epub 2011 Feb 17.
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