Cancer Institute/Hospital, Chinese Academy of Medical Sciences, Beijing, People's Republic of China; Yale University School of Public Health, New Haven, Connecticut.
Am J Hematol. 2013 Jul;88(7):606-11. doi: 10.1002/ajh.23463. Epub 2013 May 30.
We conducted a population-based case-control study in Connecticut women to test the hypothesis that genetic variations in DNA repair pathway genes may modify the relationship between body mass index (BMI) and risk of non-Hodgkin lymphoma (NHL). Compared to those with BMI <25, women with BMI ≥25 had significantly increased risk of NHL among women who carried BRCA1 (rs799917) CT/TT, ERCC2 (rs13181) AA, XRCC1 (rs1799782) CC, and WRN (rs1801195) GG genotypes, but no increase in NHL risk among women who carried BRCA1 CC, ERCC2 AC/CC, XRCC1 CT/TT, and WRN GT/TT genotypes. A significant interaction with BMI was only observed for WRN (rs1801195; P = 0.004) for T-cell lymphoma and ERCC2 (rs13181; P = 0.002) for diffuse large B-cell lymphoma. The results suggest that common genetic variation in DNA repair pathway genes may modify the association between BMI and NHL risk.
我们在康涅狄格州女性中进行了一项基于人群的病例对照研究，以检验以下假设，即 DNA 修复途径基因的遗传变异可能会改变体重指数（BMI）与非霍奇金淋巴瘤（NHL）风险之间的关系。与 BMI<25 的女性相比，携带 BRCA1（rs799917）CT/TT、ERCC2（rs13181）AA、XRCC1（rs1799782）CC 和 WRN（rs1801195）GG 基因型的 BMI≥25 的女性患 NHL 的风险显著增加，但携带 BRCA1 CC、ERCC2 AC/CC、XRCC1 CT/TT 和 WRN GT/TT 基因型的女性 NHL 风险并未增加。仅在 T 细胞淋巴瘤中观察到 WRN（rs1801195；P=0.004）和弥漫性大 B 细胞淋巴瘤中 ERCC2（rs13181；P=0.002）与 BMI 之间存在显著的交互作用。结果表明，DNA 修复途径基因的常见遗传变异可能会改变 BMI 与 NHL 风险之间的关联。
