Stevens A, Schabet M, Wiethölter H, Schott K
Department of Neurology, University of Tübingen, F.R.G.
J Neuroimmunol. 1990 Jul;28(2):141-51. doi: 10.1016/0165-5728(90)90028-l.
The effects of therapeutic prednisolone treatment on experimental allergic neuritis (EAN) in Lewis rats were evaluated in a controlled clinical and electrophysiological study. Since steroid therapy has been suspected to cause relapsing or chronic disease, monitoring was extended over 200 days. Short-term steroid treatment (5 days of 15 mg/kg prednisolone, n = 8) with sudden steroid withdrawal was compared with long-term application (30 days, beginning at 7.5 mg/kg) in descending dosage (n = 8). The experiment included saline-injected controls (n = 8) and controls for stress possibly exerted by the handling of the animals. Treatment was begun at the onset of clinical signs. The clinical and electrophysiological data indicated that deterioration, recovery and mild (insignificant) relapse (after day 30 and day 108) occurred in all groups at the same time. Both steroid application schemes significantly (p less than 0.03) attenuated the severity and shortened the duration of EAN. Relapse was not aggravated after steroid treatment. The clinical course and electrophysiological findings were unaltered by the experimental procedures and by mild experimental stress.
在一项对照临床和电生理研究中，评估了治疗性泼尼松龙治疗对Lewis大鼠实验性变态反应性神经炎（EAN）的影响。由于怀疑类固醇疗法会导致疾病复发或慢性化，监测时间延长至200天。将短期类固醇治疗（15mg/kg泼尼松龙，共5天，n = 8）并突然停用类固醇与长期应用（30天，从7.5mg/kg开始）并逐渐减量（n = 8）进行比较。实验包括注射生理盐水的对照组（n = 8）以及针对动物处理可能施加的应激的对照组。在临床症状出现时开始治疗。临床和电生理数据表明，所有组均同时出现病情恶化、恢复以及轻度（不显著）复发（第30天和第108天后）。两种类固醇应用方案均显著（p < 0.03）减轻了EAN的严重程度并缩短了病程。类固醇治疗后复发并未加重。临床病程和电生理结果不受实验操作和轻度实验应激的影响。
