Oderfeld-Nowak B, Brosnan C, Cervone A, Oderfeld J, Ledeen R W
Department of Neurophysiology, Nencki Institute of Experimental Biology, Warsaw, Poland.
Acta Neurobiol Exp (Wars). 1990;50(4-5):495-504.
The effect of gangliosides on the clinical expression of experimental allergic neuritis (EAN), a PNS counterpart of experimental allergic encephalomyelitis (EAE), was tested in Lewis rats sensitized with bovine intradural root myelin in complete Freund's adjuvant (CFA). A mixture of bovine brain gangliosides (GM1, GD1a, GD1b, GT1b) was injected intramuscularly at a daily dose of 20 mg per kg beginning 6 days post inoculation. The results show that GA treatment considerably reduces the incidence of mortality, delays its occurrence, and reduces the severity of clinical scores when either the whole population or survivors only are considered. Benefit from GA treatment appeared roughly proportional to disease severity. The neuronotrophic and anti-inflammatory effects possibly play a role in GA protecting effect.
在完全弗氏佐剂（CFA）中用牛硬膜内神经根髓磷脂致敏的Lewis大鼠中，测试了神经节苷脂对实验性变应性神经炎（EAN）临床症状的影响，EAN是实验性变应性脑脊髓炎（EAE）在外周神经系统的对应物。从接种后第6天开始，每天以每千克20毫克的剂量肌肉注射牛脑神经节苷脂混合物（GM1、GD1a、GD1b、GT1b）。结果表明，无论考虑全部大鼠还是仅考虑存活大鼠，神经节苷脂治疗均能显著降低死亡率、延迟死亡发生，并降低临床评分的严重程度。神经节苷脂治疗的益处似乎与疾病严重程度大致成比例。神经营养和抗炎作用可能在神经节苷脂的保护作用中发挥作用。
