磷脂酰丝氨酸可抑制Lewis大鼠中髓磷脂诱导的实验性变应性神经炎（EAN）。

Phosphatidylserine suppresses myelin-induced experimental allergic neuritis (EAN) in Lewis rats.

作者信息

Maeda Y, Maeda R, Prineas J W, Ledeen R W

机构信息

Department of Neurosciences, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark 07103.

出版信息

J Neuropathol Exp Neurol. 1994 Nov;53(6):672-7. doi: 10.1097/00005072-199411000-00014.

DOI:10.1097/00005072-199411000-00014

PMID:7964907

Abstract

Phosphatidylserine administered as an aqueous dispersion to myelin-induced experimental allergic neuritis rats had a significant effect on disease course. Intraperitoneal injections of 30 mg/kg were given daily beginning at the onset of disease and continued for 14 days. Clinical severity and mortality were markedly reduced by this treatment as compared to saline controls. Improved clinical outcome was associated with a reduction in peripheral nerve pathology. A possible mechanism involving tumor necrosis factor is discussed.

摘要

以水分散体形式给予髓磷脂诱导的实验性变应性神经炎大鼠的磷脂酰丝氨酸对病程有显著影响。从疾病发作开始每天腹腔注射30mg/kg，并持续14天。与生理盐水对照组相比，这种治疗显著降低了临床严重程度和死亡率。临床结果的改善与周围神经病理学的减轻有关。讨论了一种涉及肿瘤坏死因子的可能机制。