Department of Stomatognathic Physiology, Central Hospital, Västerås, Sweden ; Centre for Clinical Research, Uppsala University, Central Hospital, Västerås, Sweden ; Faculty of Odontology, Malmö University, Malmö, Sweden.
Nat Sci Sleep. 2012 Aug 22;4:89-96. doi: 10.2147/NSS.S33849. Print 2012.
The objective of this study was to evaluate the effect of oral appliance (OA) treatment on cognitive functions in patients with obstructive sleep apnea (OSA).
In a prospective study, 50 male patients with verified moderate-to-severe OSA received an OA with mandibular advancement. The cognitive functions assessed included working memory, vigilance, executive functioning, and mental pace, measured before as well as after 6 months of treatment. Somnography was used to measure physiological treatment effects. Forty-three patients completed the 6-month follow-up study.
All domains of cognitive functioning measured improved after 6 months of treatment with an OA (P <; 0.001). The apnea/hypopnea- and oxygen desaturation-indices decreased significantly after treatment (P <; 0.01). An obvious treatment response was reached in 60% of the patients, and 54% of the patients had recovered ie, had normalized breathing during sleep.
OA with mandibular advancement is a treatment modality for the physiological symptoms of OSA, and may have a positive impact on cognitive functions, after only 6 months of treatment.
本研究旨在评估口腔矫治器（OA）治疗对阻塞性睡眠呼吸暂停（OSA）患者认知功能的影响。
在一项前瞻性研究中，50 名经证实患有中重度 OSA 的男性患者接受了下颌前伸式 OA 治疗。在治疗前和治疗 6 个月后，评估了认知功能，包括工作记忆、警觉性、执行功能和心理速度。睡眠监测用于测量生理治疗效果。43 名患者完成了 6 个月的随访研究。
OA 治疗 6 个月后，所有测量的认知功能领域均得到改善（P < 0.001）。治疗后，呼吸暂停/低通气-和氧减指数显著降低（P < 0.01）。60%的患者达到了明显的治疗反应，54%的患者恢复了 ie，即睡眠期间呼吸正常。
下颌前伸式 OA 是 OSA 生理症状的治疗方法，仅治疗 6 个月后，可能对认知功能产生积极影响。
