Fu Mei-Yuan, Hu Guo-Hua, Zhou Xiang-Feng, He Bao-Xiang, He Li-Xing, Huang Bing-Lun, Gao Su-Hua
Clinical Experimental Room, Medical School of Jinhua Polytechnic, Jinhua 321017, Zhejiang Province, China.
Zhongguo Zhen Jiu. 2013 Feb;33(2):117-20.
To explore the dynamic change and clinical efficacy of acupuncture at Sifeng (EX-UE 10) on appetite regulating factors in the serum of infantile anorexia.
Eighty cases, in compliance with the diagnostic criteria, aged from 3 to 6 years were randomized into an acupuncture group and a medication group, 40 cases in each one. Additionally, a healthy control group (30 cases) was set up. In the acupuncture group, the pricking method was adopted at Sifeng (EX-UE 10) with the three-edged needle. A few light yellow, transparent viscous liquid or blood was squeezed out after pricking. The treatment was given once a week, for 4 weeks totally. In the medication group, erkangning syrup was administered, 3 times a day, for 4 weeks totally. The ghrelin, leptin and neuropeptide Y (NPY), and the clinical efficacy were observed before and after treatment in each group.
The levels of ghrelin and NPY before treatment in acupuncture group and the medication group were lower apparently than those in the healthy control group (all P < 0.01), but the level of leptin was higher appa-rently than that in the healthy control group (P < 0.01). After treatment, the levels of ghrelin and NPY were higher apparently than those before treatment in the acupuncture group (both P < 0.01), and the level of leptin was lower apparently than that before treatment (P < 0.01). All of the above indices in the acupuncture group were improved obviously after treatment as compared with those in the medication group (all P < 0.01). The remarkable and effective rate were 82.5% (33/40) and 32.5% (13/40) and the total effective rate were 95.0% (38/40) and 45.0% (18/40) in the acupuncture group and medication group separately, the results in the acupuncture group were superior to the medication group (both P < 0.01).
Acupuncture at Sifeng (EX-UE 10) effectively promotes the secretion of ghrelin and NPY and inhibit leptin. It effectively promotes appetite for the children and the efficacy is superior to erkangning syrup.
探讨针刺四缝（EX-UE 10）对小儿厌食症患儿血清食欲调节因子的动态变化及临床疗效。
将80例符合诊断标准、年龄3～6岁的患儿随机分为针刺组和药物组，每组40例。另设健康对照组30例。针刺组采用三棱针点刺四缝（EX-UE 10），针刺后挤出少许淡黄色、透明黏稠液体或血液。每周治疗1次，共治疗4周。药物组给予儿康宁糖浆口服，每日3次，共治疗4周。观察两组治疗前后胃泌素、瘦素、神经肽Y（NPY）水平及临床疗效。
针刺组和药物组治疗前胃泌素和NPY水平明显低于健康对照组（均P<0.01），而瘦素水平明显高于健康对照组（P<0.01）。治疗后，针刺组胃泌素和NPY水平明显高于治疗前（均P<0.01），瘦素水平明显低于治疗前（P<0.01）。针刺组上述各项指标治疗后与药物组比较均明显改善（均P<0.01）。针刺组显效率为82.5%（33/40）、有效率为32.5%（13/40），总有效率为95.0%（38/40）；药物组显效率为32.5%（13/40）、有效率为45.0%（18/40），针刺组疗效优于药物组（均P<0.01）。
针刺四缝（EX-UE 10）能有效促进胃泌素和NPY分泌，抑制瘦素分泌，有效增进患儿食欲，疗效优于儿康宁糖浆。
