钌催化的 C-H 单羟基化和双羟基化合成 2-氨基酚和杂环。
Synthesis of 2-aminophenols and heterocycles by Ru-catalyzed C-H mono- and dihydroxylation.
机构信息
MOE Key Laboratory of Protein Sciences, Department of Pharmacology and Pharmaceutical Sciences, School of Medicine and School of Life Sciences, Tsinghua University , Beijing 100084, China.
出版信息
Org Lett. 2013 May 17;15(10):2334-7. doi: 10.1021/ol400437a. Epub 2013 Apr 26.
PMID:23621763
Abstract
A novel and efficient synthesis of 2-aminophenols, 2-aminobenzene-1,3-diols, and heterocycles through Ru-catalyzed C-H mono- and dihydroxylation of anilides has been developed with a new directing group strategy. The reaction demonstrates excellent reactivity, regioselectivity, good functional group tolerance, and high yields.
摘要
发展了一种新的导向基团策略，通过 Ru 催化的酰胺的 C-H 单和双羟化反应，实现了 2-氨基酚、2-氨基苯-1,3-二醇和杂环的新颖高效合成。该反应表现出优异的反应活性、区域选择性、良好的官能团耐受性和高收率。
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