钌（II）催化酯作为有效导向基团的芳基羟化反应合成。
Ruthenium(II)-catalyzed synthesis of hydroxylated arenes with ester as an effective directing group.
机构信息
Department of Pharmacology and Pharmaceutical Sciences, School of Medicine and School of Life Sciences, Tsinghua University, Beijing 100084, China.
出版信息
Org Lett. 2012 Jun 1;14(11):2874-7. doi: 10.1021/ol301104n. Epub 2012 May 14.
An unprecedented Ru(II) catalyzed ortho-hydroxylation has been developed for the facile synthesis of a variety of multifunctionalized arenes from easily accessible ethyl benzoates with ester as an efficient directing group. Both the TFA/TFAA cosolvent system and oxidants serve as the critical success factors in this transformation. The reaction demonstrates excellent reactivity, good functional group tolerance, and high yields.
发展了一种前所未有的 Ru(II) 催化的邻位羟化反应，可从易得的苯甲酸乙酯出发，通过酯基作为有效的导向基团，简便地合成各种多功能芳基化合物。TFA/TFAA 共溶剂体系和氧化剂都是该转化的关键成功因素。该反应具有极好的反应活性、良好的官能团耐受性和高收率。
Zotero 插件