Benjamin N, Robinson B F, Graham J G, Wilson R B
Department of Medicine, St. George's Hospital Medical School, London, UK.
J Hum Hypertens. 1990 Jun;4(3):273-6.
The cholesterol:phospholipid ratio was measured in platelet plasma membrane, red blood cell (RBC) membranes, low density lipoprotein (LDL) and whole plasma in patients with primary hypertension and in matched normal controls. The cholesterol:phospholipid ratio was raised in the platelet membrane from hypertensive patients compared with that from normal controls (0.65 +/- 0.03 vs 0.53 +/- 0.02: mean +/- SEM; P less than 0.01). The ratio observed in RBC membranes, LDL and whole blood was similar in the two groups. If this abnormality in the lipid composition of platelet plasma membrane is present in other cells it could account for some of the changes in cell membrane function that have been described in hypertension.
在原发性高血压患者及相匹配的正常对照者中，对血小板质膜、红细胞（RBC）膜、低密度脂蛋白（LDL）和全血中的胆固醇与磷脂比值进行了测定。与正常对照者相比，高血压患者血小板膜中的胆固醇与磷脂比值升高（0.65±0.03对0.53±0.02：均值±标准误；P<0.01）。两组在RBC膜、LDL和全血中观察到的比值相似。如果血小板质膜脂质组成的这种异常存在于其他细胞中，那么它可能是高血压中所描述的细胞膜功能某些变化的原因。
