Esposito Felice, Grimod Gianluca, Cavallo Luigi M, Lanterna Luigi, Biroli Francesco, Cappabianca Paolo
Department of Neurosciences and Reproductive and Odontostomatological Sciences, Division of Neurosurgery, Università degli Studi di Napoli Federico II, Naples, Italy.
Clin Neurol Neurosurg. 2013 Sep;115(9):1735-7. doi: 10.1016/j.clineuro.2013.03.013. Epub 2013 Apr 23.
To assess long-term efficacy of the collagen-only biomatrix as a dural substitute in a large case series.
We reviewed a prospectively acquired database of patients who underwent neurosurgical surgeries in whom the dural substitute was used and who were the subject of two previous studied with shorter follow-ups.
The present study was conducted on 111 subjects of the original 209 patients. No late complications, nor local or systemic toxicity were observed during the observational period. As a matter of facts, 5 patients (4.5%) underwent reoperation for different reasons and 2 out of 5 experienced subcutaneous fluid collections; another case (0.9%), already reported in our previous studies, developed a CSF leak after an endoscopic endonasal operation for an intra-suprasellar arachnoid cyst.
Our data further confirm that the collagen-only biomatrix derived from horse equine tendon is a safe and effective dural substitute for routine neurosurgical procedures.
在一个大型病例系列中评估仅含胶原蛋白的生物基质作为硬脑膜替代物的长期疗效。
我们回顾了一个前瞻性获取的数据库，该数据库包含接受神经外科手术且使用了硬脑膜替代物的患者，这些患者也是之前两项随访时间较短研究的对象。
本研究针对最初209例患者中的111例进行。在观察期内未观察到晚期并发症、局部或全身毒性。事实上，5例患者（4.5%）因不同原因接受了再次手术，其中2例出现皮下积液；另有1例（0.9%），我们之前的研究已报道过，在因鞍上蛛网膜囊肿接受内镜鼻内手术后出现脑脊液漏。
我们的数据进一步证实，源自马肌腱的仅含胶原蛋白的生物基质是常规神经外科手术中一种安全有效的硬脑膜替代物。
