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Crit Rev Oncol Hematol. 2013 Oct;88(1):144-53. doi: 10.1016/j.critrevonc.2013.03.007. Epub 2013 Apr 25.
Cancer is a disease that occurs due to the uncontrolled multiplication of cells that invade nearby tissues and can spread to other parts of the body. An increased incidence of cancer in the world has led to an increase in oncology research and in the number of oncology trials. Well designed oncology clinical trials are a key part of developing effective anti-cancer drugs. This review focuses on statistical considerations in the design and analysis of oncology clinical trials.
癌症是一种由于细胞失控增殖而发生的疾病，这些细胞会侵袭附近的组织，并可能扩散到身体的其他部位。全球癌症发病率的增加导致了肿瘤学研究和肿瘤试验数量的增加。精心设计的肿瘤学临床试验是开发有效抗癌药物的关键部分。本文综述了肿瘤学临床试验设计和分析中的统计学考虑因素。
