Luketich J D, Rigberg D, Banchs R, Shinkwin M, Sigal R, Daly J, Mullen J L
Harrison Department of Surgical Research, Hospital of the University of Pennsylvania, Philadelphia 19104.
J Surg Res. 1990 Jun;48(6):573-8. doi: 10.1016/0022-4804(90)90233-r.
Single snapshot measurements of resting energy expenditure (REE) suggest that hypermetabolism contributes to cancer cachexia, but tumor impact on total 24-hr energy expenditure (TEE) is unknown. Automated multicage indirect calorimetry was employed to measure daily energy expenditure in adult Buffalo rats (n = 16) randomized to tumor inoculation or controls. Measurements included baseline REE, activity EE (AEE), thermic response to food (TEF), and TEE. Rats (n = 16) were randomized. Metabolic measurements, tumor size, and body weight were recorded weekly. Animals were sacrificed at Week 5 for analysis of host and tumor composition. Significant depletion of total lean body mass occurred in TB rats (greater than 15% wt loss, ANOVA P less than 0.001) which inversely correlated with tumor growth (r = -0.81, P less than 0.001). REE, TEF, AEE, and TEE did not change in controls (ANOVA P = n.s.). In TB rats, a 19.5% increase in REE occurred (119.4 +/- 3.3 to 138.7 +/- 1.8 kcal/kg LBM/day, P less than 0.01). TEE remained unchanged (157.3 +/- 5.6 vs 152.9 +/- 3.6 kcal/kg LBM/day, P = n.s.) due to a 66% decrease in AEE (32.9 +/- 3.1 to 10.5 +/- 1.7 kcal/kg LBM/day, P = 0.01). TEF did not change (4.7 +/- 0.8 vs 5.0 +/- 0.3 kcal/kg LBM/day, P = n.s.). Both TB and controls demonstrated a decreased REE in response to a 24-hr fast (7.9% vs 4.8%, P = n.s.). Respiratory quotient decreased in both groups when comparing fed to fasted values: TB (0.86 to 0.76) and controls (0.86 to 0.71), but the decline was greater in controls (P = 0.04).(ABSTRACT TRUNCATED AT 250 WORDS)
静息能量消耗（REE）的单次快照测量表明，高代谢与癌症恶病质有关，但肿瘤对24小时总能量消耗（TEE）的影响尚不清楚。采用自动多笼间接测热法测量成年布法罗大鼠（n = 16）的每日能量消耗，这些大鼠被随机分为接种肿瘤组或对照组。测量指标包括基线REE、活动能量消耗（AEE）、对食物的热反应（TEF）和TEE。大鼠（n = 16）被随机分组。每周记录代谢测量值、肿瘤大小和体重。在第5周处死动物以分析宿主和肿瘤组成。接种肿瘤的大鼠出现了显著的总体瘦体重消耗（体重减轻超过15%，方差分析P < 0.001），这与肿瘤生长呈负相关（r = -0.81，P < 0.001）。对照组的REE、TEF、AEE和TEE没有变化（方差分析P = 无统计学意义）。在接种肿瘤的大鼠中，REE增加了19.5%（从119.4 ± 3.3增至138.7 ± 1.8千卡/千克瘦体重/天，P < 0.01）。由于AEE下降了66%（从32.9 ± 3.1降至10.5 ± 1.7千卡/千克瘦体重/天，P = 0.01），TEE保持不变（157.3 ± 5.6对152.9 ± 3.6千卡/千克瘦体重/天，P = 无统计学意义）。TEF没有变化（4.7 ± 0.8对5.0 ± 0.3千卡/千克瘦体重/天，P = 无统计学意义）。接种肿瘤的大鼠和对照组在禁食24小时后REE均下降（分别为7.9%和4.8%，P = 无统计学意义）。两组在进食与禁食状态下比较时呼吸商均下降：接种肿瘤的大鼠（从0.86降至0.76）和对照组（从0.86降至0.71），但对照组下降幅度更大（P = 0.04）。（摘要截断于250字）
