Department of Organic Chemistry, Bioorganic Chemistry and Biotechnology, Silesian University of Technology, Krzywoustego 4, Gliwice 44-100, Poland.
J Control Release. 2013 Jul 10;169(1-2):126-40. doi: 10.1016/j.jconrel.2013.04.009. Epub 2013 Apr 24.
MWCNTs in the 'nanotube-drug' hybrids can play a role of carriers or additives (enhancers) in the more complex formulations. This work reviews qualitative and quantitative analyses of Drug Delivery Systems (DDSs) based on multi-wall carbon nanotubes (MWCNTs) and their chemically modified analogues (mainly oxidised MWCNTs). A special emphasis was placed on the chemical interactions between drug molecules and the nanotube carrier critical both in the stage of preparation/synthesis of the hybrids and liberation of the drug.
在“纳米管-药物”混合物中,多壁碳纳米管 (MWCNTs) 可以作为载体或添加剂(增强剂)存在于更复杂的配方中。本工作综述了基于多壁碳纳米管 (MWCNTs) 及其化学修饰类似物(主要是氧化 MWCNTs)的药物传递系统 (DDS) 的定性和定量分析。特别强调了药物分子与纳米管载体之间的化学相互作用,这在混合物的制备/合成阶段和药物释放阶段都至关重要。