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无催化剂、一锅法、三组分合成绿色介质中 5-氨基-1,3-芳基-1H-吡唑-4-甲腈。

Catalyst-free, one-pot, three-component synthesis of 5-amino-1,3-aryl-₁Η-pyrazole-4-carbonitriles in green media.

机构信息

Department of Chemistry, Faculty of Sciences, Persian Gulf University, 75169 , Bushehr, Iran.

出版信息

Mol Divers. 2013 Aug;17(3):459-69. doi: 10.1007/s11030-013-9445-y. Epub 2013 Apr 27.

DOI:10.1007/s11030-013-9445-y
PMID:23624645
Abstract

An efficient, one-pot, three-component synthesis of various biologically important heterocyclic compounds is described via a tandem Knoevengel-cyclo condensation reaction of aromatic aldehydes, malono derivatives, and phenyl hydrazine derivatives in water and ethanol at room temperature.

摘要

描述了一种通过芳香醛、丙二腈衍生物和苯肼衍生物在水和乙醇中的串联 Knoevenagel-环缩合反应，在室温下高效、一锅法、三组分合成各种重要生物杂环化合物的方法。

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本文引用的文献

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Highly selective synthesis of pyrazole and spiropyrazoline phosphonates via base-assisted reaction of the Bestmann-Ohira reagent with enones.通过 Bestmann-Ohira 试剂与烯酮的碱基辅助反应，高选择性合成吡唑和螺吡唑啉膦酸酯。
J Org Chem. 2011 Jun 3;76(11):4764-70. doi: 10.1021/jo200582z. Epub 2011 May 3.
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Design, synthesis and structure-activity relationship study of novel pyrazole-based heterocycles as potential antitumor agents.新型吡唑基杂环类化合物的设计、合成及构效关系研究，作为潜在的抗肿瘤药物。
Eur J Med Chem. 2010 Dec;45(12):5887-98. doi: 10.1016/j.ejmech.2010.09.054. Epub 2010 Oct 1.
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Catalyst-free one-pot four component synthesis of polysubstituted imidazoles in neutral ionic liquid 1-butyl-3-methylimidazolium bromide.
由三氧化二锑催化合成具有高度取代咪唑核心的新型有机硅化合物。
Mol Divers. 2015 Feb;19(1):29-41. doi: 10.1007/s11030-014-9551-5. Epub 2014 Sep 19.
在中性离子液体1-丁基-3-甲基咪唑溴化物中无催化剂一锅法四组分合成多取代咪唑。
J Comb Chem. 2010 Nov 8;12(6):844-9. doi: 10.1021/cc100097m. Epub 2010 Sep 9.
4
Efficient synthesis of pyrazoles: oxidative C-C/N-N bond-formation cascade.吡唑的高效合成：氧化C-C/N-N键形成级联反应
Angew Chem Int Ed Engl. 2010 Oct 11;49(42):7790-4. doi: 10.1002/anie.201002389.
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Pyrazoles and pyrazolides-flexible synthons in self-assembly.吡唑和吡唑化物——自组装中的柔性合成子
Dalton Trans. 2009 Mar 28(12):2059-73. doi: 10.1039/b815577a. Epub 2009 Jan 23.
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Domino cu-catalyzed C--N coupling/hydroamidation: a highly efficient synthesis of nitrogen heterocycles.多米诺铜催化的C-N偶联/氢酰胺化反应：氮杂环的高效合成
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