自闭症谱系障碍中静息态伽马振荡的非典型偏侧性。
Atypical laterality of resting gamma oscillations in autism spectrum disorders.
作者信息
Maxwell Christina R, Villalobos Michele E, Schultz Robert T, Herpertz-Dahlmann Beate, Konrad Kerstin, Kohls Gregor
机构信息
Center for Autism Research, Children's Hospital of Philadelphia, 3535 Market St Suite 860, Philadelphia, PA, 19104, USA.
出版信息
J Autism Dev Disord. 2015 Feb;45(2):292-7. doi: 10.1007/s10803-013-1842-7.
Abstract
Abnormal brain oscillatory activity has been found in autism spectrum disorders (ASD) and proposed as a potential biomarker. While several studies have investigated gamma oscillations in ASD, none have examined resting gamma power across multiple brain regions. This study investigated resting gamma power using EEG in 15 boys with ASD and 18 age and intelligence quotient matched typically developing controls. We found a decrease in resting gamma power at right lateral electrodes in ASD. We further explored associations between gamma and ASD severity as measured by the Social Responsiveness Scale (SRS) and found a negative correlation between SRS and gamma power. We believe that our findings give further support of gamma oscillations as a potential biomarker for ASD.
摘要
在自闭症谱系障碍（ASD）中发现了异常的大脑振荡活动，并将其作为一种潜在的生物标志物。虽然有几项研究调查了ASD中的伽马振荡，但没有一项研究考察过多个脑区的静息伽马功率。本研究使用脑电图（EEG）对15名患有ASD的男孩以及18名年龄和智商匹配的发育正常的对照者的静息伽马功率进行了调查。我们发现，ASD患者右侧外侧电极处的静息伽马功率降低。我们进一步探讨了伽马与通过社会反应量表（SRS）测量的ASD严重程度之间的关联，发现SRS与伽马功率之间存在负相关。我们认为，我们的研究结果进一步支持了伽马振荡作为ASD潜在生物标志物的观点。
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