Department of Biochemistry, Faculty of Girls Science, King Abdulaziz University, Jeddah, Saudi Arabia,
J Physiol Biochem. 2013 Dec;69(4):779-83. doi: 10.1007/s13105-013-0253-8. Epub 2013 Apr 28.
The present study examined the effect of water extract (200 mg/kg body weight) of Rosmarinus officinalis L. in streptozotocin (STZ)-induced diabetic rats for 21 days. The hepatoprotective effects were investigated in the liver tissues sections. There was a significant increase in serum liver biochemical parameters (aspartate aminotransferase, alanine transaminase, and alkaline phosphatase), accompanied by a significant decrease in the level of total protein and albumin in the STZ-induced rats when compared with that of the normal group. The high-dose treatment group (200 mg/kg body wt) significantly restored the elevated liver function enzymes near to normal. This study revealed that rosemary extracts exerted a hepatoprotective effect. The results indicate that the extract exhibits the protective effect on tissues and prove its potentials as an antidiabetic agent.
本研究考察了迷迭香（Rosmarinus officinalis L.）水提取物（200mg/kg 体重）对链脲佐菌素（STZ）诱导的糖尿病大鼠连续 21 天给药的影响。在肝组织切片中研究了其肝保护作用。与正常组相比，STZ 诱导的大鼠血清肝生化参数（天冬氨酸转氨酶、丙氨酸转氨酶和碱性磷酸酶）显著升高，总蛋白和白蛋白水平显著降低。高剂量治疗组（200mg/kg 体重）可显著使升高的肝功能酶恢复接近正常。本研究表明，迷迭香提取物具有肝保护作用。结果表明，提取物对组织具有保护作用，证明了其作为抗糖尿病药物的潜力。
