Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, California, USA; Biomedical Physics Interdepartmental Program, University of California, Los Angeles, California, USA.
J Magn Reson Imaging. 2014 Feb;39(2):339-45. doi: 10.1002/jmri.24154. Epub 2013 Apr 26.
To evaluate Off Resonance Insensitive Complementary SPAtial Modulation of Magnetization (ORI-CSPAMM) and Fourier Analysis of STimulated echoes (FAST) for the quantification of left ventricular (LV) systolic and diastolic function and compare it with the previously validated FAST+SPAMM technique.
LV short-axis tagged images were acquired with ORI-CSPAMM and SPAMM in healthy volunteers (n = 13). The FAST method was used to automatically estimate LV systolic and diastolic twist parameters from rotation of the stimulated echo and stimulated anti-echo about the middle of k-space subsequent to ∼3 min of user interaction.
There was no significant difference between measures obtained for FAST+ORI-CSPAMM and FAST+SPAMM for mean peak twist (12.9 ± 3.4° versus 11.9 ± 4.0°; P = 0.4), torsion (3.3 ± 0.9°/cm versus 2.9 ± 1.0°/cm, P = 0.3), circumferential-longitudinal shear angle (9.1 ± 3.0° versus 8.2 ± 3.4°, P = 0.3), twisting rate (79.6 ± 20.2°/s versus 68.2 ± 23.4°/s, P = 0.1), untwisting rate (-117.5 ± 31.4°/s versus -106.6 ± 32.4°/s, P = 0.3), normalized untwisting rate (-9.3 ± 2.0/s versus -9.9 ± 4.4/s, P = 0.7), and time of peak twist (281 ± 18 ms versus 293 ± 25 ms, P = 0.04). FAST+ORI-CSPAMM also provided measures of duration of untwisting (148 ± 21 ms) and the ratio of rapid untwisting to peak twist (0.9 ± 0.3). Bland-Altman analysis of FAST+ORI-CSPAMM and FAST+SPAMM twist data demonstrates excellent agreement with a bias of -0.1° and 95% confidence intervals of (-1.0°, 3.2°).
FAST+ORI-CSPAMM is a semi-automated method that provides a quick and quantitative assessment of LV systolic and diastolic twist and torsion. ORI-CSPAMM corrects off-resonance accrued during tagging preparation and readout and visibly removes chemical shift from the tagging pattern, which confers greater robustness to the derived quantitative measures.
评估离共振无敏感互补空间调制的磁化（ORI-CSPAMM）和受激回波的傅里叶分析（FAST）在定量评估左心室（LV）收缩和舒张功能方面的作用，并将其与之前经过验证的 FAST+SPAMM 技术进行比较。
在健康志愿者（n=13）中使用 ORI-CSPAMM 和 SPAMM 采集 LV 短轴标记图像。FAST 方法用于自动从刺激回波和刺激反回波围绕中间的 k 空间的旋转中估计 LV 收缩和舒张扭转参数，随后需要大约 3 分钟的用户交互。
FAST+ORI-CSPAMM 和 FAST+SPAMM 测量的平均峰值扭转（12.9±3.4°与 11.9±4.0°；P=0.4）、扭转（3.3±0.9°/cm 与 2.9±1.0°/cm，P=0.3）、周向-纵向剪切角（9.1±3.0°与 8.2±3.4°，P=0.3）、扭转率（79.6±20.2°/s 与 68.2±23.4°/s，P=0.1）、解旋率（-117.5±31.4°/s 与 -106.6±32.4°/s，P=0.3）、归一化解旋率（-9.3±2.0/s 与 -9.9±4.4/s，P=0.7）和峰值扭转时间（281±18 ms 与 293±25 ms，P=0.04）之间没有显著差异。FAST+ORI-CSPAMM 还提供了解旋持续时间（148±21 ms）和快速解旋与峰值扭转之比（0.9±0.3）的测量值。FAST+ORI-CSPAMM 和 FAST+SPAMM 扭转数据的 Bland-Altman 分析表明，两者具有极好的一致性，偏差为-0.1°，95%置信区间为（-1.0°，3.2°）。
FAST+ORI-CSPAMM 是一种半自动方法，可快速定量评估 LV 收缩和舒张扭转和扭转。ORI-CSPAMM 校正了在标记制备和读出过程中产生的离共振，并从标记模式中明显去除了化学位移，从而使衍生的定量测量值更具鲁棒性。
