McCauley J, Van Thiel D H, Starzl T E, Puschett J B
Department of Medicine, University of Pittsburgh School of Medicine, Pa.
Nephron. 1990;55(2):121-8. doi: 10.1159/000185938.
We have performed a retrospective review of the incidence and etiologies of acute renal failure (ARF) in 105 adult patients receiving liver transplants. The prevalence of chronic renal failure was also determined. ARF occurred in 94.2% of these patients. Acute tubular necrosis was the leading cause of ARF and was associated with the highest mortality. Factors associated with increased mortality included: (1) peak serum creatinine greater than 3 mg/dl, (2) multiple liver transplants and (3) the need for dialysis. Pretransplant renal failure did not increase mortality. Chronic renal failure developed in 83% of patients at latest follow-up (mean: 30.5 +/- 7.9 months).
我们对105例接受肝移植的成年患者急性肾衰竭（ARF）的发病率及病因进行了回顾性研究。同时也确定了慢性肾衰竭的患病率。这些患者中94.2%发生了ARF。急性肾小管坏死是ARF的主要原因，且死亡率最高。与死亡率增加相关的因素包括：（1）血清肌酐峰值大于3mg/dl，（2）多次肝移植，以及（3）需要透析。移植前肾衰竭并未增加死亡率。在最新随访时（平均：30.5±7.9个月），83%的患者出现了慢性肾衰竭。
