Palestine A G, Nussenblatt R B, Chan C C
Am J Med. 1984 Oct;77(4):652-6. doi: 10.1016/0002-9343(84)90356-5.
Twenty-six patients with ocular inflammatory disorders of presumed autoimmune origin were treated with oral cyclosporine. Cyclosporine is a potent T cell regulatory agent that has been utilized extensively in organ transplantation. In general, the patients in this study did not have chronic debilitating illnesses that are observed in organ transplant recipients, did not receive corticosteroids in addition to cyclosporine, and did not undergo any surgical procedure during their treatment. This study describes the observed adverse reactions in this group of patients not undergoing transplantation. The reported side effects of cyclosporine in organ transplant recipients have included nephrotoxicity, hepatotoxicity, infections, lymphoma, hirsutism, gingivitis, and central nervous system toxicity. Side effects were observed that were similar to those in previous reports, but the severity of the nephrotoxicity and hepatotoxicity appeared to be less. Nephrotoxicity occurred in eight patients and hepatotoxicity occurred in one patient. No lymphomas were seen. Hypertension and anemia each were observed in six patients. In addition, previously unreported effects of hyperuricemia, elevated sedimentation rate, and hidradenitis were observed. However, the overall severity of the side effects did not seriously affect the usage of cyclosporine in the patients in this study. Cyclosporine may be useful in the treatment of other autoimmune diseases.
26例推测为自身免疫性起源的眼部炎性疾病患者接受了口服环孢素治疗。环孢素是一种强效的T细胞调节剂，已广泛应用于器官移植。总体而言，本研究中的患者没有器官移植受者中常见的慢性衰弱性疾病，除环孢素外未接受皮质类固醇治疗，且在治疗期间未接受任何外科手术。本研究描述了这组未接受移植的患者中观察到的不良反应。环孢素在器官移植受者中报告的副作用包括肾毒性、肝毒性、感染、淋巴瘤、多毛症、牙龈炎和中枢神经系统毒性。观察到的副作用与先前报告的相似，但肾毒性和肝毒性的严重程度似乎较轻。8例患者出现肾毒性，1例患者出现肝毒性。未发现淋巴瘤。6例患者出现高血压和贫血。此外，还观察到高尿酸血症、血沉升高和汗腺炎等先前未报告的影响。然而，副作用的总体严重程度并未严重影响本研究中患者使用环孢素。环孢素可能对治疗其他自身免疫性疾病有用。
