Sasaki Takahide, Fukumori Daisuke, Yamamoto Kentaroh, Yamamoto Fumio, Igimi Hirotsune, Yamashita Yuichi
Department of Gastroenterological Surgery, Fukuoka University School of Medicine, Fukuoka, Imari, Japan ; Department of Surgery, Yamamoto Memorial Hospital, Imari, Japan.
Case Rep Gastroenterol. 2013 Mar 20;7(1):147-52. doi: 10.1159/000350501. Print 2013 Jan.
Spontaneous regression of hepatocellular carcinoma (HCC) is an extraordinary phenomenon that occurs rarely. While more than 80 cases have been described, most have been established via radiological findings or examination of biopsy tissues rather than via pathological examination of a resected specimen. The present report describes a purported case of spontaneous regression of HCC as indicated by radiological examination. Subsequent immunostaining of surgically resected specimens revealed viable cancer cells, though only necrotic tissues were seen on hematoxylin and eosin staining. These data indicate that viable cancer cells may still be present even if imaging findings suggest spontaneous regression of HCC. Therefore, these patients should receive aggressive treatment similar to that used for patients with established HCC.
肝细胞癌（HCC）的自发消退是一种罕见的特殊现象。虽然已报道了80多例，但大多数是通过影像学检查或活检组织检查确诊，而非通过切除标本的病理检查确诊。本报告描述了一例经影像学检查提示为HCC自发消退的疑似病例。随后对手术切除标本进行免疫染色发现仍有存活的癌细胞，尽管苏木精-伊红染色仅见坏死组织。这些数据表明，即使影像学检查提示HCC自发消退，仍可能存在存活的癌细胞。因此，这些患者应接受与确诊HCC患者类似的积极治疗。
