Mayhall Kim, Ghayouri Masoumeh, Henry Katherine, Margin Veronica, Copolla Domeinico, Shackelford Rodney
Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, La., USA.
Case Rep Oncol. 2013 Mar 21;6(1):158-62. doi: 10.1159/000350464. Print 2013 Jan.
The 1986 Chernobyl nuclear accident resulted in radiation exposures throughout much of Europe, with the highest exposures within the city of Pripyat, Ukraine, where the accident occurred. We report a woman who was exposed to the Chernobyl accident at age 13. Beginning in her early thirties, she experienced several years of upper abdominal pain that became progressively more severe. At age 35, she underwent upper endoscopy and gastric biopsy. Histological examination revealed a signet ring cell (SRC) gastric carcinoma. The tumor was discovered at an advanced stage and proved unresectable. She died 3 months following her diagnosis. The mean age for SRC gastric carcinoma diagnosis is about 62 years; the median survival following diagnosis is 13 months. The early appearance and aggressive clinical course of this malignancy in relation to the Chernobyl nuclear accident is discussed.
1986年的切尔诺贝利核事故导致欧洲大部分地区受到辐射，事故发生地乌克兰普里皮亚季市的辐射暴露量最高。我们报告了一名13岁时暴露于切尔诺贝利事故的女性。从三十出头开始，她经历了数年的上腹部疼痛，且疼痛逐渐加重。35岁时，她接受了上消化道内镜检查和胃活检。组织学检查显示为印戒细胞（SRC）胃癌。该肿瘤发现时已处于晚期，无法切除。她在确诊后3个月去世。SRC胃癌的平均诊断年龄约为62岁；确诊后的中位生存期为13个月。本文讨论了这种恶性肿瘤与切尔诺贝利核事故相关的早期出现及侵袭性临床病程。
