Chyatte D, Reilly J, Tilson M D
Section of Neurosurgery, Yale School of Medicine, New Haven, Connecticut.
Neurosurgery. 1990 Jun;26(6):939-43. doi: 10.1097/00006123-199006000-00003.
Elastin and reticular fibers were identified using standard histological strains in middle cerebral arteries taken from patients who had died from aneurysmal subarachnoid hemorrhage and control patients who did not have cerebral aneurysms. Examination of cerebral arteries from normal individuals revealed a dense network of fine reticular fibers in the arterial media that were uniformly distributed. Computerized morphometric analysis indicated that reticular fibers in the arterial media of cerebral arteries were significantly decreased in patients with aneurysms. In addition, these fibers were irregularly distributed and shortened when compared to those seen in control arteries. In both patients with aneurysms and control patients, elastin fibers were limited almost exclusively to the internal elastin lamina. No differences were observed in the appearance or content of elastin fibers in control patients and patients with aneurysm. Although other explanations cannot be excluded, these observations are consistent with the hypothesis that "intrinsic" abnormalities in the walls of cerebral arteries lead to conditions that favor the formation and rupture of cerebral aneurysms.
使用标准组织学染色方法，对死于动脉瘤性蛛网膜下腔出血的患者以及无脑动脉瘤的对照患者的大脑中动脉进行弹性蛋白和网状纤维鉴定。对正常个体大脑动脉的检查显示，动脉中膜存在密集的细网状纤维网络，且分布均匀。计算机形态计量分析表明，动脉瘤患者大脑动脉中膜的网状纤维显著减少。此外，与对照动脉中的纤维相比，这些纤维分布不规则且缩短。在动脉瘤患者和对照患者中，弹性纤维几乎仅局限于内弹性膜。对照患者和动脉瘤患者的弹性纤维在外观或含量上未观察到差异。尽管不能排除其他解释，但这些观察结果与以下假设一致，即脑动脉壁的“内在”异常导致有利于脑动脉瘤形成和破裂的情况。
