Ostergaard J R, Reske-Nielsen E, Oxlund H
Neurosurgery. 1987 Apr;20(4):554-8. doi: 10.1227/00006123-198704000-00008.
Histological and morphometric studies on the collagenous, reticular, and elastic fibers of the tunica media were performed on the middle cerebral and brachial arteries of patients with ruptured intracranial saccular aneurysms and controls. There was no difference between aneurysm patients and controls in the amount of collagenous and elastic fibers. The amount of reticular fibers was, however, reduced about 35% in aneurysm patients within both the middle cerebral artery (P less than 0.01) and the brachial artery (P less than 0.02). The reticular fibers were irregularly distributed and often appeared shorter and coarser than normally. The observations point to a generalized abnormality of the arterial bed in some patients with rupture of saccular aneurysms.
对颅内囊状动脉瘤破裂患者及对照组的大脑中动脉和肱动脉进行了中膜胶原纤维、网状纤维和弹性纤维的组织学及形态计量学研究。动脉瘤患者与对照组的胶原纤维和弹性纤维数量无差异。然而，在大脑中动脉（P<0.01）和肱动脉（P<0.02）中，动脉瘤患者的网状纤维数量减少了约35%。网状纤维分布不规则，且通常比正常情况下更短、更粗。这些观察结果表明，部分囊状动脉瘤破裂患者存在动脉床的普遍异常。
