Mostajeran Fateme, Arbabi Bahareh
Department of Obstetrics and Gynecology, Isfahan University of Medical Sciences, Isfahan, Iran.
Int J Prev Med. 2013 Mar;4(3):322-6.
Preeclampsia is an important cause of maternal morbidity and mortality with unclear cause. It is believed that inflammation plays an important role in the pathogenesis of preeclampsia. Periodontal disease is a chronic inflammatory infectious condition which commonly involves humans. Recently, chronic infection was linked to atherosclerosis. Atherosclerosis shares some histopathologic features with uteroplacental atherosis of preeclamptic women. This study was aimed to investigate the presence of periopathogenic bacteria in the placental tissue of preeclamptic women, and compare it with women with normal pregnancy.
Samples were obtained from 23 placentas of preeclamptic women and from 23 age-matched healthy pregnant women. Qualitative polymerase chain reaction was performed to detect the presence of five periopathogenic bacteria.
There was no significant difference between the two groups regarding the relative frequency of women with different types of periopathogenic bacterial infection of the placenta. In addition, there was no significant difference in the number of women with any type of infection of the placenta (regardless of the type of periopathogenic bacteria) [14 (61%) mothers with placental infection in the case group vs. 18 (78%) mothers in the control group, P value = 0.16].
This study did not show any significant difference between preeclamptic women and healthy women with normal pregnancy regarding the periopathogenic bacterial profile of the placenta.
子痫前期是孕产妇发病和死亡的重要原因，其病因尚不明确。人们认为炎症在子痫前期的发病机制中起重要作用。牙周病是一种常见于人类的慢性炎症性感染性疾病。最近，慢性感染与动脉粥样硬化有关。动脉粥样硬化与子痫前期女性的子宫胎盘动脉粥样硬化有一些组织病理学特征。本研究旨在调查子痫前期女性胎盘组织中牙周致病菌的存在情况，并与正常妊娠女性进行比较。
从23例子痫前期女性的胎盘和23例年龄匹配的健康孕妇的胎盘中获取样本。采用定性聚合酶链反应检测五种牙周致病菌的存在情况。
两组胎盘不同类型牙周致病菌感染女性的相对频率无显著差异。此外，胎盘有任何类型感染（无论牙周致病菌类型）的女性数量也无显著差异[病例组14例（61%）胎盘感染母亲与对照组18例（78%）母亲，P值 = 0.16]。
本研究未显示子痫前期女性与正常妊娠健康女性在胎盘牙周致病菌谱方面有任何显著差异。
