Khader Yousef S, Jibreal Muna, Al-Omiri Mahmoud, Amarin Zouhair
Department of Community Medicine, Public Health, and Family Medicine, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.
J Periodontol. 2006 Oct;77(10):1681-7. doi: 10.1902/jop.2006.050463.
It was hypothesized that periodontal diseases may increase the risk of preeclampsia. To test this hypothesis, this study was conducted to determine the association between periodontal parameters and preeclampsia among women in the north of Jordan.
A case-control study was conducted among women who gave birth at Princes Badea Teaching Hospital between September 2004 and May 2005. A total of 115 preeclamptic women and 230 randomly selected controls were analyzed. The number of teeth, restorations, decayed tooth surfaces, and clinical periodontal parameters were determined within 24 hours after delivery. Information regarding participants' demographics, antenatal history, and family history were collected through personal interviews.
After adjustment for potential confounding factors, there were no statistical differences between preeclamptic cases and normotensive controls with regard to mean periodontal probing depth, mean clinical attachment loss, mean gingival recession, mean plaque index, and mean gingival index. In addition, there were no significant differences in the percentages of sites with periodontal probing depth >/=3 or >/=4 mm, percentages of sites with clinical attachment loss >/=3 mm, number of filled surfaces, and number of missing teeth. Only the number of decayed surfaces was found to be associated with increased odds of preeclampsia (adjusted odds ratio of 1.13; 95% confidence interval of 1.02 and 1.25).
This study did not support the hypothesis of an association between periodontal parameters and preeclampsia.
据推测,牙周疾病可能会增加先兆子痫的风险。为验证这一推测,本研究旨在确定约旦北部女性牙周参数与先兆子痫之间的关联。
在2004年9月至2005年5月期间于巴迪亚王子教学医院分娩的女性中开展了一项病例对照研究。共分析了115例先兆子痫女性和230例随机选取的对照。在分娩后24小时内确定牙齿数量、修复体、龋坏牙面以及临床牙周参数。通过个人访谈收集参与者的人口统计学信息、产前病史和家族病史。
在对潜在混杂因素进行调整后,先兆子痫病例组与血压正常的对照组在平均牙周探诊深度、平均临床附着丧失、平均牙龈退缩、平均菌斑指数和平均牙龈指数方面无统计学差异。此外,牙周探诊深度≥3或≥4mm的部位百分比、临床附着丧失≥3mm的部位百分比、充填面数量和缺失牙数量也无显著差异。仅发现龋坏面数量与先兆子痫几率增加相关(调整后的优势比为1.13;95%置信区间为1.02至1.25)。
本研究不支持牙周参数与先兆子痫之间存在关联的推测。