Campbell B G, Jones B W, Burnet J
Department of Chemical Pathology, Princess Alexandra Hospital, Brisbane.
Pathology. 1990 Jan;22(1):45-8. doi: 10.3109/00313029009061424.
This report describes the diagnostic problem caused by an atypical immunoglobulin-bound creatine kinase isoenzyme in a patient who had a myocardial infarction. In the presence of this atypical isoenzyme, creatine kinase isoenzyme electrophoresis was of no help in determining whether myocardial infarction had occurred. A diagnosis of myocardial infarction was confirmed by carrying out lactate dehydrogenase isoenzyme electrophoresis and finding the characteristic increase in LD1/LD2 ratio and by following the total creatine kinase, aspartate aminotransferase and lactate dehydrogenase activities over a 5-day period. Further investigations were carried out which characterized the atypical isoenzyme as an uncommon type: creatine kinase-BB bound to immunoglobulin A lambda.
本报告描述了一名心肌梗死患者体内非典型免疫球蛋白结合肌酸激酶同工酶所引发的诊断问题。在这种非典型同工酶存在的情况下，肌酸激酶同工酶电泳对于确定是否发生心肌梗死并无帮助。通过进行乳酸脱氢酶同工酶电泳并发现LD1/LD2比值特征性升高，以及在5天内跟踪总肌酸激酶、天冬氨酸转氨酶和乳酸脱氢酶活性，确诊了心肌梗死。进一步的研究将这种非典型同工酶鉴定为一种不常见的类型：与免疫球蛋白Aλ结合的肌酸激酶-BB。
